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Biological/Research Material for H1N1 Influenza Virus Vaccine Research

Posted Oct 11 2009 5:00pm

Description of Invention:
Offered for licensing is a recombinant attenuated vaccinia virus, MVA, that expresses the haemagglutinin (HA) and nucleoprotein (NP) of influenza virus A/PR/8/34 (H1N1). The virus has been shown to stimulate protective immunity to influenza virus in mice.

The materials can be used for research purposes and in particular in the area of influenza virus vaccines.

The related publications listed below demonstrate the usefulness of this biological material in influenza virus vaccine research.

Research reagents useful in research and development in the area of H1N1 Influenza virus vaccines.

Development Status:
Fully developed. The usefulness of the materials has been shown in Dr. Moss' laboratory.

Bernard Moss (NIAID)
Linda S Wyatt (NIAID)

Patent Status:
HHS, Reference No. E-260-2009/0

Research Material -- patent protection is not being pursued for this technology

Related Technologies:
US, Patent No. 7,045,313, Issued 16 May 2006, Reference No. E-552-1982/2
US, Patent No. 7,015,024, Issued 21 Mar 2006, Reference No. E-552-1982/2
US, Patent No. 6,998,252, Issued 14 Feb 2006, Reference No. E-552-1982/2
US, Patent No. 7,045,136, Issued 16 May 2006, Reference No. E-552-1982/2
PCT, Application No. PCT/US83/01863 filed 28 Nov 1983, Reference No. E-552-1982/2

An abstract describing these technologies may be viewed at

Relevant Publication:
  1. G Sutter, LS Wyatt, PL Foley, JR Bennink, B Moss. A recombinant vector derived from the host range-restricted and highly attenuated MVA strain of vaccinia virus stimulates protective immunity in mice to influenza virus. Vaccine 1994 Aug;12(11):1032-1040. [ PubMed abs ]
  2. B Bender, CA Rowe, SF Taylor, LS Wyatt, B Moss, PA Small Jr. Oral immunization with a replication-deficient recombinant vaccinia virus protects mice against influenza. J Virol. 1996 Sep;70(9): 6418-6424. [ PubMed abs ]

Licensing Status:
Available for licensing.

Infectious Diseases
Infectious Diseases - Vaccines
Infectious Diseases - Research Materials

For Additional Information Please Contact:
Susan Ano Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Phone: 301-435-5515
Fax: 301-402-0220

Ref No: 2022

Updated: 10/2009

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