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Bioelectric Fingerprint IDs Cancer

Posted Feb 17 2013 10:07pm
Posted on Feb. 15, 2013, 6 a.m. in Cancer Diagnostics

Bioelectric signals underlie an important set of control mechanisms that regulate how cells grow and multiply.  Michael Levin, from Tufts University (Massachusetts, USA), and colleagues have  discovered a bioelectric signal that can identify cells that are likely to develop into tumors. The researchers also found that they could lower the incidence of cancerous cells by manipulating the electrical charge across cells' membranes. Using a frog embryo model, the researchers induced tumor growth by injecting the samples with mRNAs (messenger RNA) encoding well-recognized human oncogenes Gli1, KrasG12D, and Xrel3. The embryos developed tumor-like growths that are associated with human cancers such as melanoma, leukemia, lung cancer, and rhabdomyosarcoma (a soft tissue cancer that most often affects children). When the researchers analyzed the tumor cells using a membrane voltage-sensitive dye and fluorescence microscopy, they observed that the tumor sites had unique depolarized membrane voltage relative to surrounding tissue – suggesting a distinctive bioelectric signal. 

Chernet, B. T., Levin, M.  “Transmembrane voltage potential is an essential cellular parameter for the detection and control of tumor development in a Xenopus model.”  Disease Models & Mechanisms, 8 February 2013.

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Anti-Aging Forum MLDP Join A4M
Tip #125 - Shop - Don't Drop
Older women living in neighborhoods in which they have access to facilities like parks, trails, or shops have considerably higher levels of activity that those who live outside 20 minutes walking distance of such locations.

Researchers from University of Pittsburgh Medical Center (Pennsylvania, USA) found that women who lived within a department, discount, or hardware store averaged 6,808 steps a day, versus 5,015 steps who did not live near such stores.

Whenever possible, opt to walk to your local market or appointment; or, park centrally to your errand locations and walk between each.
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