Binding Domains from Plasmodium vivax and Plasmodium falciparum Erythrocyte Binding Proteins
Posted Feb 27 2011 7:00pm
Description of Invention: Despite considerable research efforts worldwide it has not been possible to design an effective vaccine against malaria. The present invention provides the basis for an effective vaccine against the blood state of malaria infections.
This invention relates to the identification of functional domains of Plasmodium proteins which play a role in erythrocyte binding and invasion. The inventors have identified the erythrocyte binding domains of the sialic acid binding protein (SABP) of P. falciparum and the Duffy antigen binding protein (DABP) of P. vivax. The erythrocyte binding domains can be used as vaccines to induce immune responses which block erythrocyte binding and invasion by P. falciparum and P. vivax merozoites.
Inventors: Kim L Sim (NIAID) Chetan Chitnis (NIAID) Louis H Miller (NIAID) David S Peterson (NIAID) Xin-zhuan Su (NIAID) Thomas E Wellems (NIAID)