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Bacterially Expressed Influenza Virus Recombinant HA Proteins for Vaccine and Diagnostic Applications

Posted Jul 01 2010 5:00pm

Description of Invention:
Pandemic H1N1 influenza virus is a recently emergent strain of influenza virus that the World Health Organization (WHO) estimates has killed at least 14,711 people worldwide. Avian influenza viruses are emerging health threats with pandemic potential. Due to their global health implications, there has been a massive international effort to produce protective vaccines against these influenza virus strains. Currently, influenza virus vaccines are produced in chicken eggs, a production method that is disadvantaged by lengthy vaccine production times and by inability to meet large-scale, global demands.

The subject technologies are specific recombinant HA proteins from H1N1, H5N1, and other strains of influenza virus produced in bacteria. The HA proteins properly fold, form oligomers, bind fetuin, agglutinate red blood cells and induce strong neutralizing antibody titers in several in vivo animal models. The key advantages of this technology are that expression of these proteins in bacteria reduces the vaccine production time and offers the ease of scalability for global usage, an issue with current production methods. The recombinant HA proteins can also be used for diagnostic applications.

Applications:
  • Vaccines for the prevention of influenza infection
  • Diagnostics for influenza virus specific antibodies


Advantages:
  • Novel vaccine candidates
  • Rapid production time


Development Status:
In vitro and in vivo data can be provided upon request.

Inventors:
Hana Golding (FDA)
Surender Khurana (FDA)


Patent Status:
HHS, Reference No. E-032-2010/0
US, Application No. 61/257,785 filed 03 Nov 2009
US, Application No. 61/325,216 filed 16 Apr 2010


Relevant Publication:
  1. Manuscripts are available for review under a Confidential Disclosure Agreement.


Licensing Status:
Available for licensing.


Portfolios:
Infectious Diseases
Infectious Diseases - Diagnostics
Infectious Diseases - Vaccines



For Additional Information Please Contact:
Kevin Chang Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: changke@mail.nih.gov
Phone: 301-435-5018
Fax: 301-402-0220


Ref No: 2126

Updated: 07/2010

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