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Autoimmune hepatitis and systemic sclerosis: a new overlap syndrome?

Posted Sep 11 2009 4:56pm

By I Marie and Colleague
OBJECTIVE: We report the cases of two patients with the complete CREST variant (calcinosis, Raynaud's phenomenon, oesophageal dysmotility, sclerodactyly, telangiectasia) of systemic sclerosis (SSc) who developed autoimmune hepatitis.

RESULTS: Our findings suggest that autoimmune hepatitis can be considered to be one of the liver manifestations associated with SSc. Our data also indicate that, because liver involvement may precede skin manifestations, evaluation for SSc is appropriate when autoimmune hepatitis is noted, and that the evaluation should include clinical examination, testing for antinuclear antibodies (especially for anticentromere antibodies) and nailfold capillaroscopy.

CONCLUSIONS: From a practical point of view, our two cases emphasize that suspicion of autoimmune hepatitis in SSc patients presenting with cytolytic hepatitis will help to achieve both accurate diagnosis and optimal management.

Mesh-terms: Aged; CREST Syndrome :: complications; Diagnosis, Differential; Female; Hepatitis, Autoimmune :: complications; Hepatitis, Autoimmune :: diagnosis; Human; Middle Aged;

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