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Artificial Organelles Target Toxic Compounds

Posted Aug 28 2013 10:08pm
Posted on Aug. 28, 2013, 6 a.m. in Bioengineering
Artificial Organelles Target Toxic Compounds

Researchers at the University of Basel (Switzerland) have successfully developed artificial organelles that are able to support the reduction of toxic oxygen compounds. This opens up new ways in the development of novel drugs that can influence pathological states directly inside the cell. Cornelia Palivan and colleagues have produced artificial peroxisomes that mimic the natural organelle. The cell organelle is based on polymeric nanocapsules, in which two types of enzymes are encapsulated; these enzymes are able to transform free oxygen radicals into water and oxygen.  The study authors submit that: “Our artificial peroxisome combats oxidative stress in cells, a factor in various pathologies (e.g., arthritis, Parkinson's, cancer, AIDS), and offers a versatile strategy to develop other "cell implants" for cell dysfunction.”

Tanner P, Balasubramanian V, Palivan CG.  “Aiding nature's organelles: artificial peroxisomes play their role.”  Nano Lett. 2013 Jun 12;13(6):2875-83.

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Swiss team successfully develops artificial organelles that are able to support the reduction of toxic oxygen compounds within cells.
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Anti-Aging Forum MLDP Join A4M
Tip #192 - Stay Connected
Researchers from the University of Chicago (Illinois, USA) report that social isolation may be detrimental to both mental and physical health. The team analyzed data from the National Social Life, Health, and Aging Project, a nationwide US study involving 3,000 men and women, ages 57 to 85 years. They arrived at three key findings regarding the relationships between health and different types of isolation:

• The researchers found that the most socially connected older adults are three times as likely to report very good or excellent health compared to those who are least connected, regardless of whether they feel isolated.

• The team found that older adults who feel least isolated are five times as likely to report very good or excellent health as those who feel most isolated, regardless of their actual level of social connectedness.

• They determined that social disconnectedness is not related to mental health unless it brings feelings of loneliness and isolation.

Separately, Rush University Medical Center (Illinois, USA) researchers studied 906 older men and women, testing their motor functions (including grip, pinch strength, balance, and walking) and surveying their social activity, for a period of 5 years. Those study participants with less social activity were found to have a more rapid rate of motor function decline. Specifically, the team found that every one-point decrease in social activity corresponded to an increase in functional aging of 5 years, translating to a 40% higher risk of death and 65% higher risk of disability.

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