Researchers at the University of Basel (Switzerland) have successfully developed artificial organelles that are able to support the reduction of toxic oxygen compounds. This opens up new ways in the development of novel drugs that can influence pathological states directly inside the cell. Cornelia Palivan and colleagues have produced artificial peroxisomes that mimic the natural organelle. The cell organelle is based on polymeric nanocapsules, in which two types of enzymes are encapsulated; these enzymes are able to transform free oxygen radicals into water and oxygen. The study authors submit that: “Our artificial peroxisome combats oxidative stress in cells, a factor in various pathologies (e.g., arthritis, Parkinson's, cancer, AIDS), and offers a versatile strategy to develop other "cell implants" for cell dysfunction.”
Tanner P, Balasubramanian V, Palivan CG. “Aiding nature's organelles: artificial peroxisomes play their role.” Nano Lett. 2013 Jun 12;13(6):2875-83.
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) selectively inhibit growth and induce cell death in early and late-stage oral and skin cancers.
Swiss team successfully develops artificial organelles that are able to support the reduction of toxic oxygen compounds within cells.
A week of exposure solely to natural light synchronizes the body’s circadian rhythm to the solar day.
Ups and downs in blood pressure may associate with a greater risk of cognitive impairment, among older adults.
Children and adults who consume fresh grapes, raisins and 100% grape juice tend to have healthier dietary patterns and improved nutrient intakes.
A family history of one type of cancer may not only increase the risk of the same variety of cancer, but of cancers at other sites as well.
Levels of cortisol, the stress hormone, tend to be more stable in people with positive personalities.
Low hemoglobin levels in older adults may predict a long-term risk of developing dementia.
Abundant in the amino acid, l-Citrulline, watermelon juice can relieve sore muscles.
The blood cancer non-Hodgkin lymphoma occurs at greater incidence in relation to proximity near petroleum refineries and manufacturing plants.
Bioengineered hydrogels are capable of forming synthetic scaffolds that support the formation of replacement tissues and organs.
Printer generates material that can perform some of the basic functions of the cells inside the human body.
A number of research groups are developing DNA-based circuits designed to be embedded in the human body, to monitor health and treat diseases before...
Johns Hopkins University (US) team develops a new hydrogel compound that functions as an artificial skin dressing.
UK team develops a smart nanomaterial that disrupts the blood supply to cancerous tumors.
UK team develops a new microchip muscle stimulator implant that will enable people with paraplegia to exercise their paralyzed leg muscles.
Australian researchers identify a role for perforin in killing rogue cells in the human body, potentially leading to a key breakthrough for cancer therapy.
Tip #192 - Stay Connected
Researchers from the University of Chicago (Illinois, USA) report that social isolation may be detrimental to both mental and physical health. The team analyzed data from the National Social Life, Health, and Aging Project, a nationwide US study involving 3,000 men and women, ages 57 to 85 years. They arrived at three key findings regarding the relationships between health and different types of isolation:
• The researchers found that the most socially connected older adults are three times as likely to report very good or excellent health compared to those who are least connected, regardless of whether they feel isolated.
• The team found that older adults who feel least isolated are five times as likely to report very good or excellent health as those who feel most isolated, regardless of their actual level of social connectedness.
• They determined that social disconnectedness is not related to mental health unless it brings feelings of loneliness and isolation.
Separately, Rush University Medical Center (Illinois, USA) researchers studied 906 older men and women, testing their motor functions (including grip, pinch strength, balance, and walking) and surveying their social activity, for a period of 5 years. Those study participants with less social activity were found to have a more rapid rate of motor function decline. Specifically, the team found that every one-point decrease in social activity corresponded to an increase in functional aging of 5 years, translating to a 40% higher risk of death and 65% higher risk of disability.