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Artificial Blood Vessels Hold Potential for Dialysis Patients

Posted May 28 2013 10:07pm
Posted on May 28, 2013, 6 a.m. in Regenerative Medicine

 “Off-the-shelf” blood vessels could one day reduce some complications of dialysis treatment.  A team of scientists led by Shannon L. Dahl have successfully bioengineered an artificial blood vessel by seeding human aorta cells onto a biodegradable mesh tube. In the process, a tubular vein develops in two months as the growing cells secrete proteins and the mesh support structure dissolves. The new vessel is then prepped in a way that minimizes chances of an immune reaction in the recipient. In the study, bioengineered vessels implanted in primates for six months remained durable and didn’t have the common complications of synthetic grafts: blood clots, rejection and thickening of the adjacent vein that can obstruct the graft.  Based on these results researchers have launched a multi-center European clinical trial, and the FDA has authorized a multi-center US clinical trial, to assess safety and function of biological grafts in dialysis patients who can’t have a fistula created.

Dahl S., et al.  Presentation in American Heart Association's Emerging Science Series, 24 April 2013. 

  
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Tip #168 - Activity Trumps Anxiety
A 50-year long study suggests that men and women who are physically active, emotionally calm, and organized may live longer than people with less positive personality traits such as anxiousness, anger, or fearfulness. Researchers from the National Institute of Aging (Maryland, USA) assessed personality traits among 2,359 generally healthy people who enrolled in 1958 in the Baltimore Longitudinal Study of Aging. The team found that those men and women who scored above average in measures of general activity, emotional stability, or conscientiousness lived an average of 2 to 3 years longer than those who scored below average.

Stay active and energetic, emotionally stable, and organized, disciplined, and resourceful. Not only are these the traits of professional and personal success, they might also help add years to your life.

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