ApoE3/3 - This genotype processes fat normally and does best with a moderate fat diet including slightly smaller portions of healthy fats, such as a dinner of salmon, green beans, and brown rice. Exercise is likely a good aspect to focus on.
ApoE4 - People with genotype pairings containing ApoE4 don’t use fat for fuel very well and should aim for limiting it to 20 percent of total calories, deriving more calories from complex carbohydrates and plant proteins. For example, dinner could be beans, rice, avocado, and broccoli.14
WellnessOne in Myrtle Beach and WellnessFirst in Charleston, SC have teamed up with a laboratory to test clients for ApoE variants, along with other in-depth cardiovascular and cancer biomarkers. The center can also provide dietary protocol options and guidance.15
2. Corder EH, Saunders AM, Risch NJ, Strittmatter WJ, Schmechel DE, Gaskell PC Jr, et al. Protective effect of Apolipoprotein E type 2 allele for late onset Alzheimer disease. Nat Genet. Jun 1994;7(2):180-4.
3. Van Duijn CM, Clayton D, Chandra V, Fratiglioni L, Graves AB, Heyman A, et al. Familial aggregation of Alzheimer's disease and related disorders: a collaborative re-analysis of case-control studies. EURODEM Risk Factors Research Group. Int J Epidemiol. 1991;20 Suppl 2:S13-20.
4. Huang W, Qiu C, von Strauss E, Winblad B, Fratiglioni L. APOE genotype, family history of dementia, and Alzheimer disease risk: a 6-year follow-up study. Arch Neurol. Dec 2004;61(12):1930-4.
5. Small GW, Bookheimer SY, Thompson PM, Cole GM, Huang SC, Kepe V, et al. Current and future uses of neuroimaging for cognitively impaired patients. Lancet Neurol. Feb 2008;7(2):161-72.
6. Keller L, Xu W, Wang HX, et al. The obesity related gene, FTO, interacts with APOE, and is associated with Alzheimer's disease risk: a prospective cohort study. J Alzheimers Dis. 2011;23(3):461-9.
7. Huang Y, Zheng L, Halliday G, et al. Genetic polymorphisms in sigma-1 receptor and Apolipoprotein E interact to influence the severity of Alzheimer's disease. Curr Alzheimer Res. Nov 2011;8(7):765-70.
8. Apolipoprotein E genotyping in Alzheimer's disease. National Institute on Aging/Alzheimer's Association Working Group. Lancet. Apr 20 1996;347(9008):1091-5.
9. Author (1-9) http://emedicine.medscape.com/article/1787482 (Alzheimer Disease and APOE4)
Gary W Small, MD Professor of Psychiatry and Biobehavioral Sciences, Parlow-Solomon Professor on Aging, Director of Geriatric Psychiatry, Director of the UCLA Center on Aging, University of California, Los Angeles, David Geffen School of Medicine.
Bruce Buehler, MD Professor, Department of Pediatrics and Genetics, Director RSA, University of Nebraska Medical Center.
Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference.10. http://www.hain-lifescience.de/en/products/human-genetics/ApoE/genotype-ApoE.html
11. Corbo, R.M., Scacchi, R., Apolipoprotein E (APOE) allele distribution in the world. Is APOE*4 a ‘thrifty’ allele?. Annals of Human Genetics, 1999; 63: 301–310.
12. Corella, D., Tucker, K., et. al, Alcohol drinking determines the effect of the APOE locus on LDL-cholesterol concentrations in men: the Framingham Offspring Study, Am J Clin Nutr. 2001 73: 4 736-745.
13. Berglund L. The APOE gene and diets--food (and drink) for thought. Am J Clin Nutr. 2001 Apr;73(4):669-70.
14. WellnessOne/WellnessFirst, www.wellnessoneamerica.com and www.wellnessfirstcharleston.com