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Antioxidant Formula Prior To Radiation Exposure May Prevent DNA Injury

Posted Mar 29 2011 4:57pm

A unique formulation of antioxidants taken orally before imaging with ionizing radiation minimizes cell damage, noted researchers at the Society of Interventional Radiology’s 36th Annual Scientific Meeting in Chicago, Ill. In what the researchers say is the first clinical trial of its kind, as much as a 50 percent reduction in DNA injury was observed after administering the formula prior to CT scans. “In our initial small study, we found that pre-administering to patients a proprietary antioxidant formulation resulted in a notable dose-dependent reduction in DNA injury,” said Kieran J. Murphy, M.D., FSIR, professor and vice chair, director of research and deputy chief of radiology at the University of Toronto and University Health Network, Toronto, Ontario, Canada. “This could play an important role in protecting adults and children who require imaging or a screening study,” he added.

“Pre-administering this formula before a medical imaging exam may be one of the most important tools to provide radioprotection and especially important for patients in the getting CT scans,” said Murphy. The study’s data support the theory about a protective effect during these kinds of exposure, he explained.

“There is currently a great deal of controversy in determining the cancer risks associated with medical imaging exams. Although imaging techniques, such as CT scans and mammograms, provide crucial and often life-saving information to doctors and patients, they work by irradiating people with X-rays, and there is some evidence that these can, in the long run, cause cancer,” explained Murphy. The interventional radiologist researchers responded to this patient need by exploring a way to protect individuals from these potentially harmful effects. This may be of importance to interventional and diagnostic radiologists and X-ray technologists who have occupational exposure also.

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