Antimalarial Napthylisoquinoline Alkaloids And Pharmaceutical Compositions And Medicinal Uses Thereof
Posted Jun 13 2010 5:00pm
Description of Invention: This invention provides new napthylisoquinoline alkaloid compounds, and compositions and methods of use of known and new napthylisoquinoline alkaloids, for treatment or prevention of malaria. Some compounds of this class occur naturally in plant species of the Ancistrocladaceae and Dioncophyllaceae plant families which are found in tropical Africa and southern and southeast Asia. The compounds exhibit effective antimalarial properties and offer important new weapons in the treatment of this devastating disease. The deadliest malarial parasites have become resistant to previously effective antimalarial drugs; therefore, effective new antimalarial drugs are urgently needed. These new naphthylisoquinoline compounds effectively inhibit the growth, reproduction, and pathologic effects of a broad spectrum of Plasmodia parasites, including drug-resistant strains.