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Antimalarial Inhibitors that Target the Plasmodial Surface Anion Channel (PSAC) Protein and Development of the PSAC Protein as V

Posted Oct 21 2012 8:00pm

Description of Invention:
There are two related technologies, the first being small molecule inhibitors of the malarial plasmodial surface anion channel (PSAC) and the second being the PSAC protein itself as a vaccine candidate. The PSAC protein is produced by the malaria parasite within host erythrocytes and is crucial for mediating nutrient uptake. In vitro data show that the PSAC inhibitors are able to inhibit growth of malaria parasites, have high specificity, and low toxicity. Portions of the PSAC protein are found on the outer surface of infected host erythrocytes and the protein was recently shown to be encoded by the clag3 gene. This discovery opens the possibility of developing the PSAC protein as a potential vaccine candidate against malaria.

Applications:
  • Antimalarial Drugs
  • Malaria Vaccine


Advantages:
  • Novel target against malaria
  • Small molecule inhibitors of PSAC inhibit malarial parasite growth, have low toxicity, and high specificity
  • PSAC protein is exposed on the surface of the infected host erythrocytes, making it an attractive vaccine candidate


Development Status:
  • Early-stage
  • Pre-clinical
  • In vitro data available


Inventors:
Sanjay A Desai (NIAID)


Patent Status:
HHS, Reference No. E-145-2011/0
PCT, Application No. PCT/US12/33072 filed 11 Apr 2012


Related Technologies:
US, Application No. 13/055,104 filed 20 Jan 2011, Reference No. E-202-2008/0 (Patent family filed in the U.S., Europe, Brazil, India, and China)
US, Application No. 61/083,000 filed 23 Jul 2008, Reference No. E-202-2008/0
PCT, Application No. PCT/US09/50637 filed 15 Jul 2009, Reference No. E-202-2008/0


Relevant Publication:
  1. Pillai AD, et al. [ PMID 22949525 ]
  2. Desai SA. [ PMID 22432505 ]
  3. Nguitragool W, et al. [ PMID 21620134 ]
  4. Pillai AD, et al. [ PMID 20101003 ]


Collaborative Research Opportunity:
The National Institute of Allergy and Infectious Diseases is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize Antimalarial Inhibitors that Target the Plasmodial Surface Anion Channel (PSAC) Protein. For collaboration opportunities, please contact Dana Hsu at dhsu@niaid.nih.gov or 301-451-3521.


For Licensing Information Please Contact:
Kevin Chang Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: changke@mail.nih.gov
Phone: 301-435-5018
Fax: 301-402-0220


Ref No: 2488

Updated: 10/2012

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