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Antibody Composition and Methods for the Prevention and Treatment of Lupus Nephritis

Posted Jun 15 2010 5:00pm

Description of Invention:
This technology identifies an antibody that induces a protective effect in vivo in a mouse model of lupus nephritis. Lupus is a chronic autoimmune disease that can damage various parts of the body, especially the kidneys. The lupus nephritis-model mice that were treated with this antibody experienced a dramatic increase in survival, demonstrated a reduced immune complex formation deposition in the kidneys, and displayed low levels of proteinuria as compared with untreated mice. The antibody is an autospecific anti-dsDNA IgM.

In addition, this invention may be used as a component of a predictive diagnostic kit. As lupus-related kidney disease may be asymptomatic, significant kidney damage may occur before lupus is diagnosed (lupus.org). The inventors are currently investigating whether the ratio of protective antibodies to nonprotective or pathogenic antibodies in lupus nephritis models is predictive of disease. Currently available diagnostic methods (proteinuria, creatine clearance, or kidney biopsy) are not predictive and test only for existing kidney impairment or damage.

Applications:
  • A preventative and therapeutic for lupus nephritis.
  • A component of a predictive diagnostic kit for lupus nephritis.
  • A research tool for investigation of lupus nephritis in a mouse model.


Advantages:
  • Therapeutic antibodies are unlikely to elicit side effects in patient populations, unlike many existing therapies.
  • The diagnostic would be predictive, unlike existing diagnostics.


Development Status:
Early stage, in vivo (mouse)

Inventors:
Marilyn Diaz (NIEHS)
Chuancang Jiang (NIEHS)
Ming-Lang Zhao (NIEHS)


Patent Status:
HHS, Reference No. E-156-2009/0
PCT, Application No. PCT/US10/34257 filed 10 May 2010


Relevant Publication:
  1. In preparation


Licensing Status:
Available for licensing.

Collaborative Research Opportunity:
The NIEHS is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize this technology or related laboratory research interests. Please contact Dr. Elizabeth Denholm at denholme@niehs.nih.gov or 919-541-0981 for more information.


Portfolios:
Internal Medicine
Internal Medicine - Therapeutics
In-vivo Data



For Additional Information Please Contact:
Norbert Pontzer Ph.D., J.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325 Room 23,
Rockville, MD 20852
United States
Email: pontzern@mail.nih.gov
Phone: 301-435-5502
Fax: 301-402-0220


Ref No: 2043

Updated: 06/2010

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