Antibody Composition and Methods for the Prevention and Treatment of Lupus Nephritis
Posted Jun 15 2010 5:00pm
Description of Invention: This technology identifies an antibody that induces a protective effect in vivo in a mouse model of lupus nephritis. Lupus is a chronic autoimmune disease that can damage various parts of the body, especially the kidneys. The lupus nephritis-model mice that were treated with this antibody experienced a dramatic increase in survival, demonstrated a reduced immune complex formation deposition in the kidneys, and displayed low levels of proteinuria as compared with untreated mice. The antibody is an autospecific anti-dsDNA IgM.
In addition, this invention may be used as a component of a predictive diagnostic kit. As lupus-related kidney disease may be asymptomatic, significant kidney damage may occur before lupus is diagnosed (lupus.org). The inventors are currently investigating whether the ratio of protective antibodies to nonprotective or pathogenic antibodies in lupus nephritis models is predictive of disease. Currently available diagnostic methods (proteinuria, creatine clearance, or kidney biopsy) are not predictive and test only for existing kidney impairment or damage.
A preventative and therapeutic for lupus nephritis.
A component of a predictive diagnostic kit for lupus nephritis.
A research tool for investigation of lupus nephritis in a mouse model.
Therapeutic antibodies are unlikely to elicit side effects in patient populations, unlike many existing therapies.
The diagnostic would be predictive, unlike existing diagnostics.
Development Status: Early stage, in vivo (mouse)
Inventors: Marilyn Diaz (NIEHS) Chuancang Jiang (NIEHS) Ming-Lang Zhao (NIEHS)
Collaborative Research Opportunity: The NIEHS is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize this technology or related laboratory research interests. Please contact Dr. Elizabeth Denholm at email@example.com or 919-541-0981 for more information.
Portfolios: Internal Medicine Internal Medicine - Therapeutics In-vivo Data
For Additional Information Please Contact: Norbert Pontzer Ph.D., J.D. NIH Office of Technology Transfer 6011 Executive Blvd. Suite 325
Room 23, Rockville, MD 20852 United States Email: firstname.lastname@example.org Phone: 301-435-5502 Fax: 301-402-0220