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Anti-Spasticity Medications Need Further Research

Posted Feb 03 2010 7:12pm

Only a few anti-spasticity medications used for children with cerebral palsy are backed by sufficient research to justify their useaccording to a new review of scientific literature headed by a UT Southwestern Medical Center neurologist and conducted by a national panel of interdisciplinary experts nationwide.

The findings prompted the American Academy of Neurology to release a new practice guideline on effective treatments. Dr. Mauricio Delgado-Ayalaprofessor of neurology at UT Southwestern is lead author of the guidelinewhich appears in the Jan. 26 issue of the academy’s journalNeurology.

Botulinum toxin type Asold under the brand names Botox and Dysportis effective and generally safe to relieve spasticitythe researchers found. The drugs diazepam (Valium) and tizanidine (ZanaflexSirdalud) can also be usedalthough they carry more risks.

The researchers found insufficient evidence on whether other commonly used drugs are effective or safe.

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