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Anti-H5N1 Influenza Activity of the Antiviral Protein Cyanovirin

Posted Jun 13 2010 5:00pm

Description of Invention:
Influenza A viral subtype H5N1 causes avian influenza and is currently the subject of increasing international attention. Usually, avian influenza infection is limited to birds and pigs; however H5N1 has the unique capacity to bring about severe illness and death in humans. H5N1 is highly contagious, fast spreading and rapidly evolving and therefore has the potential to cause a worldwide health epidemic.

The available technology embodies methods of using a cyanovirin-N (CV-N) peptide, protein, or nucleic acid in the prevention and/or treatment of infection. Methods, which utilize CV-N in the treatment of certain influenza strains, have previously been demonstrated. However, the novel use of CV-N to treat the H5N1 strain is unique and development of prophylactics and/or therapeutics against the virus represents a significant contribution to agriculture and public health sectors throughout the world.

Applications:
Novel therapeutics for the treatment and prevention of avian influenza

Development Status:
In vitro and early-stage animal studies have been performed

Inventors:
Barry R O'Keefe (NCI)
James B McMahon (NCI)


Patent Status:
HHS, Reference No. E-198-2006/0
US, Application No. 12/377,875 filed 18 Feb 2009


Licensing Status:
Available for licensing.

Collaborative Research Opportunity:
The NCI Molecular Targets Development Program is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize cyanovirin-N for use against H5N1 influenza. Please contact John D. Hewes, Ph.D. at 301-435-3121 or hewesj@mail.nih.gov for more information.


Portfolios:
Infectious Diseases
Infectious Diseases - Therapeutics
Infectious Diseases - Vaccines
In-vitro Data



For Additional Information Please Contact:
Sally Hu Ph.D., M.B.A.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325 Room 21,
Rockville, MD 20852
United States
Email: hus@mail.nih.gov
Phone: 301-435-5606
Fax: 301-402-0220


Ref No: 1469

Updated: 06/2010

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