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An unusual cause of acute renal failure in systemic sclerosis

Posted Sep 11 2009 4:56pm

By S. Mpofu and Colleague

Background: Scleroderma renal crisis is one of the most life threatening complications of scleroderma. Enteric hyperoxaluria complicates extensive disease or resection of the small intestine in the presence of an intact colon, and is associated with calcium oxalate nephrolithiasis. This cause of renal failure may be underestimated and should be considered in all patients with malabsorption and renal failure.

Case report: A 78 year old woman with systemic sclerosis affecting the bowel developed acute renal failure caused by oxalate nephropathy.

Results: The patient’s renal failure improved on an oxalate free diet.


Keywords: scleroderma; enteric hyperoxaluria; angiotensin converting enzyme inhibitor; oxalate nephropathy; diuretics

Abbreviations: ACE, angiotensin converting enzyme; SRC, scleroderma renal crisis

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