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Aging Heart Cells Rejuvenated by Modified Stem Cells

Posted Aug 23 2012 10:09pm
Posted on Aug. 23, 2012, 6 a.m. in Stem Cell Cardio-Vascular

Scientists at San Diego State University's Heart Institute (California, USA) have successfully rejuvenated elderly heart failure patients’ heart cells with modified stem cells, suggesting a future potential for such rejuvenated cells to be used to repair damaged heart muscles.  Sadia Mohsin and colleagues biopsied elderly patients to procure stem cells, then modified them in the laboratory with PIM-1, a protein that promotes cell survival and growth.  Cells were rejuvenated when the modified stem cells enhanced activity of an enzyme called telomerase, which elongates telomere length. Telomeres are the endcaps of chromosomes that facilitate cell replication; it is currently thought that aging and disease results when telomeres break off.   The technique increased telomere length and activity, as well as increasing cardiac stem cell proliferation, all vital steps in combating heart failure.

Mohsin S., et al.  “Aging heart cells rejuvenated by modified stem cells” [BCVS-12 Abstract 62].  Presented at American Heart Association Basic Cardiovascular Sciences 2012 Scientific Session, July 23, 2012.

  
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Anti-Aging Therapeutics 13   View the Table of Contents
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28. Defend Against Atomic Pickpockets: Vitamin C
Antioxidant supplements (Vitamin A, C, E, and selenium) protect cells by neutralizing free radicals, atomic fragments that cause cellular destruction and produce metabolic waste.
Vitamin C raises "good" cholesterol (HDL), and prevents "bad" cholesterol (LDL) from oxidation, which subsequently prevents the build-up of athlerosclerotic plaques on the blood vessel wall that contribute to cardiovascular disease. In a study by University of California-Los Angeles School of Health, men who took vitamin C daily had a 45% lower risk of heart attack than men whose intake was less than the U.S. RDA.
 
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