Health knowledge made personal
Join this community!
› Share page:
Search posts:

Advancements in Early Detection for Alzheimer’s Disease

Posted Jan 15 2011 11:45pm
Posted on 2011-01-13 06:00:00 in Alzheimer's Disease | Diagnostics |

Currently there is no single test or cure for dementia, and – specifically – Alzheimer’s Disease, and scientists around the world are engaged in efforts to find treatments that prevent the disease or at least slow its progression. Jonathan M. Schott, from the University College of London (United Kingdom), and colleagues report that they have developed a diagnostic protocol to detect Alzheimer’s Disease in its very early, pre-symptomatic stages.  The researchers enrolled 105 healthy volunteers, each of whom underwent testing to detect two characteristic signs of Alzheimer’s Disease: shrinkage of the brain, and low levels of amyloid protein in the cerebrospinal fluid (CSF).  The study subjects had lumbar puncture tests to check their CSF for levels of amyloid and MRI brain scans to calculate brain shrinkage. The team found that the brains of those normal individuals with low CSF levels of amyloid (38% of the group), shrank twice as quickly as the other group. They were also five times more likely to possess the APOE4 risk gene and had higher levels of a tau, a second protein  implicated in Alzheimer's Disease. Observing that: “A significant percentage of healthy older adults have CSF profiles consistent with [Alzheimer's Disease] and increased rates of brain atrophy,” the researchers posit that: “[These patients] may be in the earliest stages of neurodegeneration. Brain atrophy may be a feasible outcome measure for [Alzheimer's Disease] prevention studies.”

Jonathan M. Schott, Jonathan W. Bartlett, Nick C. Fox and Josephine Barnes, for the Alzheimer's Disease Neuroimaging Initiative Investigators. “Increased brain atrophy rates in cognitively normal older adults with low cerebrospinal fluid A beta1-42.”  Annals of Neurology, Volume 68, Issue 6, December 2010, , Pages 825–834.

Higher measures of walking speed among older adults associate with increased longevity.
Italian researchers isolate and characterize adult fat cell-derived stem cells, leading to potentially significant tissue regeneration applications.
Betulin, a compound found in abundance in birch bark, blocks a key pathway involved in cholesterol production.
UK team reports on diagnostics to detect Alzheimer’s Disease in its very early, pre-symptomatic stages.
People who are consistently active over the course of their adulthood have a lower risk death from colon cancer, as compared to those who are sedentary.
Whitehead Institute researchers show that the multi-component mechanistic target of rapamycin complex 1 (mTORC1) in mammals is involved in the aging process
Boston University School of Medicine (US) researchers uncover the interaction between T-cells and monocytes that promotes a pro-inflammatory response.
Certain dietary patterns correlate to reduced risk of death.
Circulating levels of trans-palmitoleic acid, the fatty acid found in dairy products, may reduce the risks of type-2 diabetes.
Italian researchers report that a diet rich in antioxidant foods may protect against ischemic stroke.

View Current Anti-Aging Newsletter!
Second Opinion with Dr. Ron Klatz Solutions to improve your life, and your lifespan too.
radio tower Dr. Ronald Klatz, A4M physician founder, interviews the world’s top anti-aging experts in health, longevity, brain fitness, aesthetic beauty, and more. Get the answers to look and feel twenty years younger today.
Tune in to Second Opinion with Dr. Ronald Klatz. »
U.S. Events
Orlando Anti-Aging Conference Event
International Events
  • Bangkok |

Post a comment
Write a comment:

Related Searches