For the second time in less than a year, I had another episode of acute renal failure.
It all started with my surgery on April 10 to have my dialysis fistula ligated (“tied off”). The surgery went well; it was done under conscious sedation (no general anesthesia), and I felt great leaving the hospital. My arm was hurting, as expected, but the pain medication was effective. Being that there was no more arterial flow into the vein (which had several pseudo-aneurysms), the blood clotted and caused a thrombo-phlebitis. Now, the fistula is very hard, probably because it’s non-functioning, and has calcified.
The weekend after my surgery, I developed a fever of 102.1 and shaking chills during the night, so in the morning, I went to the Emergency Department on Sunday morning. From there I was admitted, and that’s when the problems started. I was diagnosed as having cellulitis, and being that I just had surgery, was treated aggressively with Vancomycin, in case I had MRSA. The dose was set by the pharmacist for this kidney toxic drug, and was rather high. My first dose was 3,000 mg, and the doses every 12 hours after that were 1,750 mg. The next morning, they checked a Prograf level, and that was high at 12 (unrelated to the Vancomycin). When they checked a Vanco level Monday night, it was almost double what it should have been, so they stopped it. My baseline creatinine is 1.1, and when I was admitted, it was 1.3, probably due to the Prograf being high, and being a bit dehydrated. By Tuesday, it was 1.6, and my Prograf level was 16! (it should be 6-8). Rather than do anything, they decided to discharge me with an elevated Prograf level and Acute Renal Failure! I had a rather blunt discussion with the hospitalist, and she decided to not discharge me.
The next morning, the Nephrology Fellow (a doctor training to be a Nephrologist) came in and told me I needed IV fluids and an adjustment to my Prograf dose. He ordered IV fluids at 50 ml/hr (which would be a maintenance dose for a 10 year old), and the next day, came in and told me that if my creatinine was unchanged or higher, I would need a biopsy of my kidney (which, after 4 years, I have never had/never needed). At that point, I sent an email to my Transplant Surgeon, and he was in my hospital room within an hour (he didn’t know I was admitted). He made recommendations (500 ml of saline followed by saline at 150 ml/hour, no Prograf that night) and by the next day, my creatinine was 1.5 and my Prograf level was 7.2. I was discharged on that day, and my creatinine is now down to 1.3. I did NOT need a biopsy, and my creatinine should return to baseline. The surgeon was shocked at the amount of Vancomycin I was given.
It took until today, 10 days later, for me to start feeling almost normal.
Lesson learned-whenever I’m admitted, the Transplant Surgeon WILL be consulted.