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ACE Inhibitors May Increase Risk Of Recurrence In Breast Cancer Survivors

Posted Apr 20 2011 7:29pm

ACE inhibitors, commonly used to control high blood pressure and heart failure in women, may also be associated with an increased risk of breast cancer recurrence in women, according to a study by researchers at UCLA’s Jonsson Comprehensive Cancer Center.

Beta blockers, on the other hand, which are used to control high blood pressure and cardiac arrhythmias, appear to have a protective effect, helping to prevent recurrence. When used together, beta blockers appear to help ameliorate the negative affect of ACE inhibitors, said Dr. Patricia Ganz, director of cancer prevention and control research at UCLA’s Jonsson Cancer Center and first author of the study.

Ganz characterized the results of the retrospective analysis — done using data from the Life After Cancer Epidemiology (LACE) study, which includes 1,779 Kaiser patients diagnosed with early-stage breast cancer — as “hypothesis-generating only.” She underscored that the results need further corroboration in other, larger clinical data bases.

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