A Role of Lipid Peroxidation-Derived Aldehydes to Autoimmune Diseases
Posted Sep 11 2009 4:57pm
A research about " LIPID PEROXIDATION-DERIVED ALDEHYDE-PROTEIN ADDUCTS CONTRIBUTE TO TRICHLOROETHENE-MEDIATED AUTOIMMUNITY VIA ACTIVATION OF CD4+ T CELLS" was investigated the role of lipid peroxidation in the induction and/or exacerbation of autoimmune response.
Many reports have indicated that trichloroethene is one cause of lipid peroxidation in the development of various autoimmune diseases including SLE, systemic sclerosis and fascitis, both from occupational and environmental exposures.
This study provides evidence for the existence of an association between oxidative stress and induction of autoimmunity, and strongly supports the concept that Lipid peroxidation-derived aldehyde (LPDA)- modified proteins act as an immunologic trigger by activating T lymphocytes and promoting Th1 differentiation, thus contributing to an autoimmune response.
Further studies are needed to establish a clear link between oxidative stress and autoimmunity, especially by depleting distinct lymphocyte subsets, knocking out specific genes, and dissecting the role of redox status.