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A Method to Expand a Population of Regulatory T Cells Optimal for the Treatment of Autoimmune Diseases

Posted Sep 27 2012 8:00pm

Description of Invention:
The transfusion of regulatory T cells (Tregs) has been used in the clinic to successfully prevent graft vs. host disease and is currently being evaluated in the treatment of other autoimmune diseases, such as organ graft rejection, type 1 diabetes and multiple sclerosis. Prior to transfusion, adoptive regulatory T cell transfer requires the expansion of regulatory T cells in culture; this results in a mixed population of regulatory T cells that limits the effectiveness of the transferred cells.

Scientists at the NIH have developed a method that promotes the expansion of regulatory T cells that are longer lived, more stable, and more suppressive of the autoimmune response. By supplementing T cell cultures with DNA oligonucleotides, the inventors were able to enrich the regulatory T cell population that enhanced the suppression of the autoimmune response. This method has the potential to more effectively generate regulatory T cells for the treatment of autoimmune diseases.

Applications:
Treatment of autoimmune diseases, such as Graft vs. Host Disease, Organ Graft Rejection Type 1 Diabetes, Multiple Sclerosis.

Advantages:
  • More effective therapy when compared to traditional T cell expansion methods.
  • Expansion method is inexpensive and similar to current methods.


Development Status:
In vitro data available

Inventors:
Yong Chan Kim (NIAID)
Ethan M Shevach (NIAID)


Patent Status:
HHS, Reference No. E-279-2011/0
US, Application No. 61/576,837 filed 16 Dec 2011


Relevant Publication:
  1. Kim Y, et al. [ PMID 22294730 ]



For Licensing Information Please Contact:
John Stansberry Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: js852e@nih.gov
Phone: 301-435-5236
Fax: 301-402-0220


Ref No: 2481

Updated: 09/2012

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