Hi Melissa,  Yes, I am another Melissa!  ;) 

I have been on Savella for about 4 months.  I have not tried Cymbalta.  My doc describes Savella as part Lexapro/part Adderall.  I also take D-ribose(1/2-1 scoop per day),10 mg Oxycontin-(not as much since starting the Savella), Vicodin(5/500 only as needed), Provigil(1/2 per day), Flexeril(5mg at night), and vitamins(Vit D, E, B, Magnesium, Omegas).  

I have had some really great moments and some really bad moments on Savella(muscle pain, fatigue...).  It is really rocky in the beginning.  After about 2 months, I started to feel really good(like 75% better!!).  Now on my 4th month, I seem to be rolling backwards.  Not sure if it is a flare up, or if my meds are not mixing well?  I have read to stick it out, because it is worth it(I read on the clinical trial recaps, that up to month 10 you might have to stick it out?!).  I am now back to 50 mg a day(only the pm dose).  I am uncertain wether I will stay on it or not.  If it starts to get better again, I will stay on it!  

Anyone else having the same problem?  I am curious to know if any one around month 4 saw any eye twitches(I have had this for 4 wks) or a leveling effect, like it just suddenly stopped working?  I would really appreciate any info!  :)     -melissa m. 

Hi Melissa!  That certainly is a lot of medication to be dealing with.  I thought I was getting bad with my Savella, Welbutrin, Yasmin, Topamax, and occasional Flexaril and Voltaren.  My doc has also given me Ultram, but I haven't taken it.

Just this week I've reached the 100mg dose with the Savella - the titration was really difficult, even though I did it way slower than it's even intended to be.  Every time I raised the dose - even by 12.5 mg - I had to go through two days of nausea, heavy feelings, dizzyness, etc.  So far I'm doing OK on the full dose though, with the minor exception that my appetite seems to be funny.  I'm also under a lot of stress though, and it's always so hard to say which factors are causing what!  As far as whether it's helping with pain, also hard to say.  I'm back to how I was feeling a couple of months ago, but that could just be this last bad flare of mine dying down on its own.

It will be interesting to see if I continue to have problems or if I do alright.  I'm somewhat concerned because both the Savella and the Wellbutrin are inhibiting the reuptake of norepinephrine - will I end up with way too much in my brain?  Or is it like, once the receptors are blocked, they're blocked, and the second drug just becomes moot in that aspect?  I should look into whether the two drugs inhibit the same receptors - although I'll admit that that science is a bit above my head.  Ugh.  Biochem.  Dealing with new drugs is always a trial.

Oh wow...Wellbutrin AND Savella?!  That is a lot of SNRIs!  Be careful.  Also, I have seen warnings about combining Ultram and Savella!

 http://www.askapatient.com/viewrating.asp?drug=22256&name=SAVELLA

http://www.drugs.com/drug-interactions/savella-with-ultram-3101-13615-2221-1474.html

 

And with Wellbutrin:

http://www.drugs.com/drug-interactions/savella-with-wellbutrin-3101-13615-440-203.html 

That may explain the stomach problems too.  I experienced more pain in the beginning of the titration.  I also went reallly slow and did two titrated packages.  I am back to 50 mg per day....and I feel so much better, than the 100 mg.  I stay away from anything that might cause serotonin symdrom(too much serotonin).  And it does effect your appetite.  One of the main side effects is ---weight loss.  

 

Hope you are feeling better now!

-melissa  :) 

oops... I meant serotonin syndrome!  ;)

Yeah, the Wellbutrin - I always thought it was an SSRI, but it isn't - it's actually a DNRI - dopamine norepinephrine reuptake inhibitor.  I guess I didn't do my homework a few years back when I started taking it, which is weird of me.  Anyway, it has little to no effect on serotonin.  What concerns me is that both it and Savella are working on the norepinephrine - maybe that explains why I'm waking up so perky in the morning?  :P

The Ultram, though, I'm glad I looked it up before taking any.  It works exactly like an SNRI!  Doesn't really seem like a good idea to be doubling up, in my book.  And the same doc prescribed me both that and the Savella, in the same visit!  I need to see him again next week and I'm definitely going to bring that up - sort of shakes my confidence, you know?

Frustrating though, because I can't take Flexaril during the day and expect to function at all, and the non-steroidals destroy my stomach.  I certainly don't want to go the steroidal route, with all their side effects, unless I really and truly have to.  Have you, Melissa, or anyone else out there tried any other pain meds that don't have too many side effects or interactions?

I have taken Wellbutrin in the past and thought it was an SNRI!!!  Wow. Thanks for the info!!!

 I totally understand about having your confidence shaken!  I was going to an accupuncturist, who had me write down everything I was taking...she came back with a white face and explained all the negative interactions between all the herbal stuff with the prescriptions!  I stopped taking almost everything and started over.  We have so many symptoms, that it gets mixed up when they are used to writing prescriptions for everything!  I have too many doctors who don't talk to each other enough(rhuematologist, internist, accupuncturist, chiropracter, massage therapist, and the doctor who is an MD/who pracitces natural medicine!).  I now carry a list of all the meds to all my appointments, just in case.   

As for pain meds, I used to loooove Vioxx, but, my stomach was a wreck.  And it was taken off the market.  

I have been taking Oxycontin 10mg(NOT to be confused with Oxycodone-that is the generic.-which made my stomach the worst(migranes, vomiting).  But, Oxycontin is great.  It is 8 hr time released and has nothing else in it(like aspirin).  I never take more than 10mg.  I am fearful of becoming addicted, so I don't take it every day.  I have been taking it for about 1 1/2 yrs.  It is the only thing that works for me. Vicodin helps too, but, I try to avoid taking it, due to stomach issues(it has aspirin/ibuprofin or some sort of NSAID).  Also, Oxycontin will keep me up at night, so I use that during the day(when I am NOT at work) and at night Vicodin(since it lets me sleep).  I really don't take anything when I am at work.  Every so often I take Liquid Advil and Alka-seltzer(if my stomach is upset and I have pain).    

Hope this helps!! 

I would love to hear anyone else's suggestions too.  :) 

Nurses sometimes are the worst patients. I am an OR nurse. I went through years of pain,(constant dull burning with ocasional sharp shooting pains down my right arm, some numbness and tingling, but rarely. the worse of the problems was the lower back where i also had a constant burning in my lower back with sharp shoothing pains into both buttoks and down the right leg,lots of intermittent numbness, tingling, stabbing in my foot) from a car accident in 1/2006 that i "dealt with" until the symtoms worsened i couldnt take it anymore in 1/2008. Went to a pain management dr and started with an MRI of my neck, showing 2 bulging discs and severe muscle spasm, I had no curvature of the spine that should be there.The dr wanted to do epidurals and trigger point injections, I wanted a second opinion. Next, to to Spine Specialist. Prescribed physical therapy, and some flexiril and said thats all he could do for my neck. Next concerned with my lower back he ordered an MRI of my lower spine, that was never ordered by the doctor that treated me following my car accident. Surprise! 2 herniated discs, L-4 L-5 and L-5 S-1 both comproising the left exiting nerveroot. Again, PT this time some Skelaxin since the flexiril did nothing but make me sleep, and a referrel to a neurologist. Inconsistent neuro but basically "within normal limits". This doc decided I needed an MRI of my hip since I had almost abnormal results and my complaints of groin, joint, buttock and leg pain. Labral hip tear. Constant refferal from doctor to doctor every test showing something but nothing "major". Until I injured myself at work this year moving a 450lb patient, landed a trip to the ER. Finally now the pain is being taken seriously. After months of solumedrol, percocet, valium, prednisone, oxycontin increasing the doses...continuing PT for the 8 millionth time.I got a little better as I always do with PT, but then i regress after a few months. Went back to work after 2 1/2 months, apparently too soon, since I was only back at work for 3 weeks 12 1/2 hour days. I couldnt make it through a single week without leaving early because of the pain. Back out and still currently out of work. My physchiatrist, the only doctor that REALLY listens to me, I guess its his job, decided to put me on Savella. I have been taking Wellbutrin for years and had just recently lowered the dose before the work accident because things were so good in my life and I wanted to try life without drugs. Apperently not in the cards for me, but the Savella has shown some promising results. Decreases the need to take anything stronger than motrin or aleve for the pain. I just hate the dry mouth! I've also noticed an increase in my BP and get hot easily, I used to always be cold. Other than that I am pleased thus far.

i found soma 250mg-500mg helpful for a while. but the one that wroks best or me is valium 5-10mg. i hear you about destroying the stomach, ive had 3 NSAID induced stomach ulcers in the last 2 years.

Wow, Elizabeth, it sounds like you've really been through it!  Nursing is an extremely demanding job, mentally and physically - I can't imagine trying to do it while in chronic pain.  I have enough trouble dealing with my cushy desk job!

Herniated discs - aagh!  We thought I had one of those back in August.  It was awful.  I was in so much pain that I couldn't even sit at my desk and had to go home from work.  It turned out, though, just to be a pinched nerve, and nothing herniated at all.  So I can't even imagine what it's like when there's real structural damage, in multiple places no less.  Is there a way for you to work in your field but not be on your feet all day?  It sounds like it's just wrecking you!  Of course I'm sure there are other factors as well, but spending so much time standing can't be helping.

I'm glad that the Savella is helping you somewhat, and I certianly hope that it continues to do so.  I'm doing pretty alright on it so far.  I'm basically back to where I was a couple of months ago, before things starting getting real bad for me and I started having troube getting to work, so I call that progress.  I can live with my old baseline.  I just can't live with where it was headed.