I can lose as much as 18 pounds with diuresis. Taking Lyrica, Cymbalta, Celebrex, Ultram, and Ambien. Have lots of rheum s/s but no firm diagnosis yet. Low grade temp, fatigue, joint and soft tissue pain, psoriatic spots that rage when other s/s flare up, edema that is HORRIBLE, but much worse in my left leg. It's double the size of my other leg. When I am full of fluid, I can't catch my breath or wear my clothes/shoes. The edema gets better then worse, but never goes away. The other s/s are most of the time. I have a few good days a month, but most days are a struggle to get up in the mornings. This has gone on for years and I am SO tired of it. Have elevated CRP and ESR always. I'm 37, a nurse and a mother and i want my life back. So much of it has been wasted with this. I'm so sick of seeing a new doc every 2 or 3 years, just trying to get some help. Leaves them scratching their heads. Please help. Some say fibro, some say all kinds of other things.