Pigment Epithelium Derived Factor: Characterization of Its Novel Biological Activity and Sequences Encoding and Expressing the P
Posted Jun 30 1996 5:00pm
Description of Invention: Pigment epithelium-derived factor (PEDF), a unique 50 kD protein secreted by retinal pigment epithelium (RPE) cells, has trophic activity. This invention describes the biological activity of PEDF, a method of enhancing neuron cell survival and a method of inhibiting glial cell proliferation, as well as purified antibodies to PEDF and an immunoassay. This technology can be used to develop therapeutics for the treatment of inflammatory, vascular, degenerative, and dystrophic diseases of the retina and central nervous system (CNS).
For Additional Information Please Contact: Susan Rucker J.D. NIH Office of Technology Transfer 6011 Executive Blvd. Suite 325
Room 30A, Rockville, MD 20852 United States Email: ruckersu@mail.nih.gov Phone: 301-435-4478 Fax: 301-402-0220
Description of Invention:
Pigment epithelium-derived factor (PEDF), a unique 50 kD protein secreted by retinal pigment epithelium (RPE) cells, has trophic activity. This invention describes the biological activity of PEDF, a method of enhancing neuron cell survival and a method of inhibiting glial cell proliferation, as well as purified antibodies to PEDF and an immunoassay. This technology can be used to develop therapeutics for the treatment of inflammatory, vascular, degenerative, and dystrophic diseases of the retina and central nervous system (CNS).
Applications:
* Alzheimer's disease * Huntington's disease * glutamate poisoning * Parkinson's disease
Advantages:
* enhance neuronal cell survival * inhibit glial cell proliferation
Inventors:
Gerald J Chader (NEI)
Takayuki Taniwaki (NINDS)
Yukihiro Sugita (NINDS)
Patent Status:
HHS, Reference No. E-185-1992/1
US, , Patent No. 5,840,686, Issued 24 Nov 1998
PCT, Application No. PCT/US95/07201 filed 06 Jun 1995
HHS, Reference No. E-185-1992/1
HHS, Reference No. E-185-1992/4
Related Technologies:
US, Patent No. 6,319,687, Issued 20 Nov 2001, Reference No. E-185-1992/3
US, Patent No. 6,451,763, Issued 17 Sep 2002, Reference No. E-185-1992/2
EIR, Reference No. E-185-1992/2
EIR, Reference No. E-185-1992/3
US, Application No. 11/201,443 filed 10 Aug 2005, Reference No. E-185-1992/3
US, Patent No. 7,511,009, Issued 31 Mar 2009, Reference No. E-185-1992/2
US, Patent No. 7,179,621, Issued 20 Feb 2007, Reference No. E-185-1992/3
Relevant Publication:
Licensing Status:
Available for exclusive or nonexclusive licensing
Portfolios:
Ophthalmology
Ophthalmology - Diagnostics
Ophthalmology - Therapeutics
Ophthalmology - Other
For Additional Information Please Contact:
Susan Rucker J.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325 Room 30A,
Rockville, MD 20852
United States
Email: ruckersu@mail.nih.gov
Phone: 301-435-4478
Fax: 301-402-0220
Ref No: 236
Updated: 07/1996