Pigment Epithelium Derived Factor: Characterization of Its Novel Biological Activity and Sequences Encoding and Expressing the P
Posted Jun 30 1996 5:00pm
Description of Invention: Pigment epithelium-derived factor (PEDF), a unique 50 kD protein secreted by retinal pigment epithelium (RPE) cells, has trophic activity. This invention describes the biological activity of PEDF, a method of enhancing neuron cell survival and a method of inhibiting glial cell proliferation, as well as purified antibodies to PEDF and an immunoassay. This technology can be used to develop therapeutics for the treatment of inflammatory, vascular, degenerative, and dystrophic diseases of the retina and central nervous system (CNS).
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