Health knowledge made personal
Join this community!
› Share page:
Search posts:

Pigment Epithelium Derived Factor: Characterization, Genomic Organization and Sequence of PEDF Gene

Posted Jun 30 1996 5:00pm

Description of Invention:
Retinal pigment epithelium (RPE) cells secrete a unique 50 kD protein. This protein, pigment epithelium-derived factor (PEDF), contains trophic activity in both the induction of neuronal cell differentiation as well as the survival of the mature neuron. This invention provides the complete genomic sequence of PEDF. It also discloses a truncated version of PEDF referred to as rPEDF, equivalent proteins, vectors comprising the nucleic acids, host cells into which the vectors have been introduced as well as a recombinant method for producing PEDF.

* research reagent * pharmaceutical composition

* recombinant method * production of large quantities

Joyce Tombran-tink (EM)
Gerald J Chader (NEI)
Fintan R Steele (NEI)
Ignacio R Rodriguez (NEI)

Patent Status:
HHS, Reference No. E-185-1992/3
US, , Patent No. 6,319,687, Issued 20 Nov 2001
US, , Patent No. 7,179,621, Issued 20 Feb 2007
PCT, Application No. PCT/US95/07201 filed 06 Jun 1995
HHS, Reference No. E-185-1992/3
HHS, Reference No. E-185-1992/4
US, Application No. 11/201,443 filed 10 Aug 2005

Related Technologies:
US, Patent No. 5,840,686, Issued 24 Nov 1998, Reference No. E-185-1992/1
US, Patent No. 6,451,763, Issued 17 Sep 2002, Reference No. E-185-1992/2
EIR, Reference No. E-185-1992/1
EIR, Reference No. E-185-1992/2
US, Patent No. 7,511,009, Issued 31 Mar 2009, Reference No. E-185-1992/2

Relevant Publication:
  1. FR Steele, GJ Chader, LV Johnson, J Tombran-Tink. Pigment epithelium-derived factor: neurotrophic activity and identification as a member of the serine protease inhibitor gene family. Proc Natl Acad Sci USA. 1993 Feb 15;90(4):1526-1530. [ PubMed abs ]
  2. SP Becerra, I Palmer, A Kumar, F Steele, J Shiloach, V Notario, GJ Chader. Overexpression of fetal human pigment epithelium-derived factor in Escherichia coli: a functionally active neurotrophic factor. J Biol Chem. 1993 Nov 5;268(31):23148-23156. [ PubMed abs ]

Licensing Status:
Available for exclusive or nonexclusive licensing

Ophthalmology - Diagnostics
Ophthalmology - Therapeutics
Ophthalmology - Other

For Additional Information Please Contact:
Susan Rucker J.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325 Room 30A,
Rockville, MD 20852
United States
Phone: 301-435-4478
Fax: 301-402-0220

Ref No: 270

Updated: 07/1996

Post a comment
Write a comment: