Animal Model for Age-Related Macular Degeneration and Methods for Use Thereof

Description of Invention:
The invention provides an animal model for the study of age-related macular degeneration. The model is an animal, any mammal, having subretinal cells, e.g. retinal pigment epithelial (RPE) cells, genetically modified to express VEGF so as to result in subretinal fibrovascular proliferation. The invention also provides a two methods: 1) for determining whether a molecule of interest can inhibit ARMD; and 2) for determining whether radiation can inhibit ARMD.

Applications:
* Screening molecules for inhibition of ARMD * Research tool - animal model

Advantages:
* Consistent model for study of ARMD * Screening tool for inhibition of ARMD

Inventors:
Karl G Csaky (NEI)


Patent Status:
HHS, Reference No. E-078-1997/0


Licensing Status:
Available for non-exclusive licensing


Portfolios:
Ophthalmology
Ophthalmology - Other
Ophthalmology - Research Materials



For Additional Information Please Contact:
Susan Rucker J.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325 Room 30A,
Rockville, MD 20852
United States
Email: ruckersu@mail.nih.gov
Phone: 301-435-4478
Fax: 301-402-0220


Ref No: 380

Updated: 09/1998