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The Nucleus Accumbens

Posted Feb 10 2010 10:33am

Final destination for addictive drugs.

The release of dopamine and serotonin in the nucleus accumbens lies at the root of active drug addiction. The pattern of neural firing that results from this surge of neurotransmitters is the “high.” It is the chemical essence of what it means to be addicted. Part of the medial forebrain bundle (MFB)which mediates punishment and rewardthe nucleus accumbens is the ultimate target for the dopamine released by the ingestion of cocainefor example.

The release of dopamine and serotonin in the nucleus accumbens appears to be the final destination of the reward pathway—the last act in the pleasure play. If you think about a drugtake a drugor crave a drugyou are lighting up the nucleus accumbens with a surge of electrochemical activity. These are essentially the same pathways that regulate our food and water-seeking behavior. By directly or indirectly influencing the molecules of pleasuredrugs and alcohol trigger key neurochemical events that are central to our feelings of both reward and disappointment. In this sensethe reward pathway is a route to both pleasure and pain.

Alcoholheroincigarettesand other drugs caused a surge of dopamine productionwhich is then released onto the nucleus accumbens. The result:  Pleasure. When scientists pipe a dopamine-mimicking substance into the nucleus accumbenstargeting dopamine D2 receptorswithdrawal symptoms are blocked in morphine-addicted rats. Similarlywhen scientists block dopamine receptors in the accumbensthe morphine-dependent rats exhibit withdrawal symptoms.

When you knock out large slices of the nucleus accumbensanimals no longer want the drugs. Soone cure for addiction has been discovered already—but surgically removing chunks of the midbrain just won’t doof course.

Dopamine is more than a primary pleasure chemical—a “happy hormone,” as it has been called. Dopamine is also the key molecule involved in the memory of pleasurable acts. Dopamine is part of the reason why we remember how much we liked getting high yesterday. The nucleus accumbens (also known as the ventral striatum) seems to be involved in modulating the emotional strength of the signals originating in the hippocampus. This implicates the hippocampus in relapseeven though this area of the brain does not light up as strongly during actual episodes of craving.

The fact that we know all this is nothing short of amazingbut it is part of a larger perspective afforded by the insights of contemporary neurobiology. We knowfor examplethat the emotion of fear arisesin large partthrough chemical changes in a peanut-sized limbic organ called the amygdala. Does this information make fear any lessshall we sayfearful? It merely locates the substrate upon which the sensation of fear is built. The building blocks are

Studies of the nucleus accumbens have demonstrated abnormal firing rates in scanned addicts who were deep into an episode of craving. The craving for a reward denied causes dopamine levels in the nucleus accumbens to crash dramaticallyas they do when users go off drugs. Dopamineserotoninand norepinephrine activity soars just as dramatically when a drug user relieves withdrawal symptoms by relapsing. Drug hunger in abstinent addicts is not all in the heador strictly psychological. Craving has a biological basis.  

Finding a way to override serotonin- and dopamine-mediated mid-brain commands is the essential key to recovery from addiction. One of the aims of a biological understanding of addiction is to tease out the mechanisms by which the reinforcing effects of addictive drugs become transformed into long-term adaptive changes in the brain.



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