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Proton Pump inhibitors and fractures

Posted Sep 23 2010 1:38pm

Here is an interesting article.  The FDA has found a link between proton pump inhibitors and fractures.  I will explain the rational behind the risk if you chose to read the article first, if not just skip to the second half.

http://www.medicinenet.com/script/main/art.asp?articlekey=116609

Proton pump inhibitors, better known as PPI's, stop acid from being formed within in the stomach.  Well, it is a little more involved, but essentially that is what they do.  The article suggests that PPI's inhibit the body's ability to absorb calcium to make strong bones.  I believe this is a right answer, but not the correct one.  Let me explain.  PPI's shut down stomach acid.  Stomach acid needs to reach a pH of at least 3-4 for proper protein digestion to take place.  Why is this important?  Well, protein is the main carrier of calcium in the blood!  Albumin in the blood holds onto 50% of the calcium in the body.  So if you cannot properly digest protein than you cannot possibly be holding enough calcium in the body to make more bone.

Let's look at it another way.  If calcium is not being absorbed properly the blood should be tested for low levels of calcium.  Rarely is calcium low in the blood.  The reason being is calcium is held at a steady state.  Now if more protein is present is allows for calcium and protein to build bone because of the availability of the substrate.  In other words, the building blocks are present for growth to occur.

Another interesting statement made is PPI's should not be used more than 3 cycles of 14 days during a one year period and never as a long term treatment!  So if you are on PPI's it is obvious there is a digestive imbalance.  Start to look at enzymes as the key to health and chiropractic adjustments for the restoration of function.

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