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Regulation Of An Enzyme In The Brain Can Suppress Appetite

Posted Jul 22 2009 11:22pm
Prolylcarboxypeptidase (PRCP) regulates alpha-melanocyte stimulating hormone (alpha-MSH). Why should you care? Studies at the Yale School of Medicine suggest your appetite will be suppressed, leading to weight loss, if PRCP can be blocked.

Studies in mice show that blocking PRCP leads to higher alpha-MSH levels -- this results in suppression of appetite.

Results were seen even after mice ate a high-fat diet designed to simulate eating "fast food" on a daily basis.

"Our research provides the first evidence that breaking down molecules in the brain that regulate metabolism is an important component of weight control."

"Our findings provide a possible new target for the development of drugs to control metabolic disorders such as obesity and type 2 diabetes."

The full article is here.

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