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The Isthmus

Posted Jul 25 2012 2:23pm

Between the two mesial canals of a mandibular molar is a very common area to find isthmus tissue.  Traditionally ignored by clinicians without a microscope, the isthmus has become a recent target for canal disinfection.  I typically reserve cleaning the isthmus as a final step in my cleaning and shaping process.  Once both canals have been cleaned, I can zoom in with the microscope and examine the area between them.  The coronal third of a canal isthmus can be troughed with a small abrasive ultrasonic tip like these from Tulsa/Dentsply: 
I prefer the 3 or 4.
The middle and apical third are trickier to access.  Often we are relying on our irrigation techniques to flush debris from the isthmus in the bottom third of the root.  There are many supplemental disinfecting protocols on the market.  Techniques range from the simplest plunging with a gutta percha cone (manual dynamic agitation) to using a complex vacuum system (apical negative pressure).  I highly recommend readers familiarize themselves with Gu's excellent review of irrigant agitation techniques found online here:  http://www.endoexperience.com/userfiles/file/review_of_irrigation_agitation.PDF .  In a research project at MCG, we found apical negative pressure (using the Endovac) to be slightly more effective than manual dynamic agitation at removing isthmus debris (Susin 2010).  More importantly, we found neither technique could consistently produce clean isthmus histology slides like this one reproduced from this article by Gutarts, Nusstein, Reader, and Beck (reprinted here:  http://www.endoexperience.com/userfiles/file/unnamed/Ultrasonic%20irrigation%20%20Gutarts%20et%20al%20JOE%202005.pdf ): 

These retreatment images by Dr. Stephen Parente show debris and necrotic tissue within the coronal third of the canal isthmus of a mandibular first molar.  The original root canal treatment was performed outside of our practice several years ago by a different dentist.  An ultrasonic tip described above was used to clean the area.
Preop.  There was some concern of finding a vertical root fracture, but there was no detectable attachment loss.
Contaminated debris within access.
Mesial isthmus exposed full of debris.
Cleaned of all debris using an ultrasonic tip.  No fractures evident.


These next images, captured from a recent mandibular molar apicoectomy of mine, demonstrate an unclean isthmus from the apical view.  The original root canal treatment was performed outside of our practice several years ago by a different dentist. 
Preop 1.  Apical radiolucency on mesial root.
Upon root resection, we see a stained black isthmus area between the canals.

A contra-angled surgical ultrasonic tip was used for the retroprep and to clean the isthmus area.
MTA was used for the retrofill.
Immediate post op radiograph.


These two case images illustrate approaches to correct unclean isthmus areas that can contribute to treatment failure.  With good magnifcation, and with advanced irrigation, we can clean the isthmus and avoid having to recommend retreatment or apicoectomy procedures.  If you have any questions or comments, please let us know.  


As always, more cases and thoughts on endodontics can continually be found on our practice's facebook page, www.facebook.com/alpharettaendo.  

Thanks to Dr. Stephen Parente for supplying the retreatment images.  Thanks to The Root Canal Anatomy Project for supplying the micro-ct image.
Gu L, Kim J, Ling J, Choi K, Pashley DH, Tay FR. Review of Contemporary Irrigant Agitation Techniques and Devices. J Endod 2009; 35: 791-804.
Gutarts R, Nusstein J, Reader A, Beck M. In vivo debridement efficacy of ultrasonic irrigation following hand-rotary instrumentation in human mandibular molars. J Endod 2005;31:166–70.
Susin L, Liu Y, Yoon JC, Parente JM, Loushine RJ, Ricucci D, Bryan T, Weller RN, Pashley DH, Tay FR.  Canal and isthmus debridement efficacies of two irrigant agitation techniques in a closed system.  Int Endod J 2010; 43: 1077-90.





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