Health knowledge made personal
Join this community!
› Share page:
Search posts:

Genetic Polymorphisms Of Interleukin-1 Alpha And Beta Associated With Early Onset Periodontitis

Posted Sep 30 1998 5:00pm

Description of Invention:
Periodontal disease occurs in 10-20% of adults, and constitutes a major cause of tooth loss. About 0.5% of U.S. adolescents between the ages of 14 to 17 years old (about 70,000) have localized early onset periodontitis and 0.1% (17,000) have the more destructive form known as generalized early onset periodontitis. Both types of early onset periodontitis often lead to tooth loss before the age of 20. Extrapolation of these figures up to age 35 leads to estimates of early onset periodontitis having a major impact on the dental health of 400,000 individuals in the U.S. population. Discovery of genetic polymorphisms at the interleukin 1 alpha and 1 beta genes significantly associated with disease risk allows genetic testing to be used to predict disease prior to onset. This can be used to target clinical efforts for disease prevention to those individuals at greatest risk. The genetic test can also justify more aggressive therapeutic treatments for individuals already affected by the early onset periodontitis who, based on their genetic profile, are predicted to exhibit very rapid disease progression.

Scott R Diehl (NIDCR)

Patent Status:
HHS, Reference No. E-076-1998/0

Dental Technology
Dental Technology - Diagnostics

For Additional Information Please Contact:
Charlene Sydnor Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Phone: 301-435-4689
Fax: 301-402-0220

Ref No: 345

Updated: 10/1998

Post a comment
Write a comment:

Related Searches