New Lung Tissue Growth Discovered: Is Some Lung Regeneration Possible?
Posted Nov 20 2012 12:00am
New lung tissue growth can occur in adults, defying previous belief (NEJM)
Lung regeneration has never been thought possible in adults. But Steven Mentzer et al from Brigham and Women’s at Harvard reported a case of a 33 year old woman who had an apparent 64% increase in the number of functioning alveoli in her left lung, during 15 year follow-up after a right pneumonectomy in 1995 for adenocarcinoma (despite her young age, she had a 30+ pack-year smoking history).
Although existing lung parenchymal tissue was known to expand after lung resection, in adults this was thought to occur through dilation of existing alveoli and supporting tissues, not de novo growth of new alveoli. However, experiments in dogs suggested lung regeneration was possible, and so researchers turned their attention to closely following this patient and her lung function after her surgery. Read the rest of this article from PulmCM.org – click here