A new University of Michigan study shows this strategy might actually be flawed. The results may hold important implications for individuals with asthma, who often experience life-threatening flare-ups due to infections with cold viruses.
The study, using a novel mouse model, shows that, in the airways, the immune response to the common cold is actually maladaptive. Mice that were engineered to have a reduced innate immune response to the common cold actually showed less not more airway inflammation and bronchoconstriction (airway spasm) following infection.
The results of this study appeared online ahead of print in the journal PLoS Pathogens, currently available online. Marc B. Hershenson, M.D., professor of pediatrics and communicable diseases and director of the division of pediatric pulmonology, is the study’s senior author.
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A new University of Michigan study shows this strategy might actually be flawed. The results may hold important implications for individuals with asthma, who often experience life-threatening flare-ups due to infections with cold viruses.
The study, using a novel mouse model, shows that, in the airways, the immune response to the common cold is actually maladaptive. Mice that were engineered to have a reduced innate immune response to the common cold actually showed less not more airway inflammation and bronchoconstriction (airway spasm) following infection.
The results of this study appeared online ahead of print in the journal PLoS Pathogens, currently available online. Marc B. Hershenson, M.D., professor of pediatrics and communicable diseases and director of the division of pediatric pulmonology, is the study’s senior author.
read the rest of this article from Science Daily - click here