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Friday’s COPD Newsletter From COPD Support, Inc.

Posted Jun 04 2010 8:05am

Volume 10, Issue 27
June 4, 2010
Joan Costello, Editor

NormOxys Inc., a biotechnology company is developing a novel class of small molecule drugs which enhance the body’s ability to deliver oxygen more efficiently to diseased tissues with oxygen deficiency. NormOxys plans to initially develop this compound as a treatment for chronic heart failure and cancer indications. The Phase 1 trial will evaluate OXY111A in healthy volunteers at escalating dose levels.

This new class of drugs can be potentially developed in a broad range of clinical indications where therapeutic benefit can be obtained through an increased, regulated delivery of oxygen to hypoxic tissue.











News items summarized in The COPD-NEWS are taken from secondary sources believed to be reliable. However, the COPD Family of Services does not verify their accuracy.

Centocor Ortho Biotech Inc. announced that it has acquired RespiVert Ltd., a privately held drug discovery company focused on developing small-molecule, inhaled therapies for the treatment of pulmonary diseases. The company’s lead compounds, RV-568 and RV-1088, narrow spectrum kinase inhibitors with a unique profile of anti-inflammatory activities, are progressing into clinical development as potential first-in-class treatments for moderate to severe asthma, COPD and Cystic Fibrosis (CF). The clinical development of RV-568 and RV-1088 will be led by RespiVert in collaboration with scientists at Centocor Research and Development, Inc.

(U.S. News and World Report) Patients who have COPD may benefit from taking beta blockers, researchers say. For years, doctors have avoided giving COPD patients these medications, based on studies in the 1980s that found beta blockers could restrict airways. But Dutch scientists found that patients given beta blockers lived longer than patients who had not taken the drugs. The only patients who may still have a problem tolerating the medication are people who have very severe, reactive asthma, the lead researcher says.

We do not accept any paid advertising. Any corporations, products, medicines (prescription or non) mentioned in this newsletter are for informational purposes only and not to be construed as an endorsement or condemnation of same.

Costa Rica has ordered the country’s largest stem cell clinic to stop offering treatment, saying there is no proof that it is effective. About 400 patients, mostly foreigners from the United States, have been treated at the Institute of Cellular Medicine in San Jose for multiple sclerosis, arthritis, spinal injuries and other illnesses.

“This isn’t allowed in any serious country in the world,” Health Minister Maria Luisa Avila said in a telephone interview. The Health Ministry several weeks ago ordered the clinic, owned by Arizona entrepreneur Neil Riordan, to stop performing the treatment, in which stem cells extracted from the patients are reinjected into their bodies. The ministry said the clinic has a permit to store the stem cells extracted from patients’ own fat tissue, bone marrow and donated umbilical cords but is not authorized to perform the treatment.

The stem cell treatments at the Costa Rica institute cost between $5,000 and $30,000. China, Thailand and Mexico also offer stem cell treatments, but Costa Rica’s stability, modern tourism infrastructure and proximity to the United States had made it a preferred destination for many patients. Riordan has a U.S. company called Aidan Products that sells, among other things, a nutritional supplement that his team says can stimulate the body’s production of blood stem cells. He also operates a stem cell clinic in Panama and is chairman of Arizona-based Medistem Inc.

A wireless monitoring system for people with COPD could allow health care workers to assess a patient’s health and the development of their disease without hindering patient movement, according to a report in the International Journal of Biomedical Engineering and Technology. The assessment of a patient’s disease state under the normal conditions of their everyday lives is becoming increasingly important in improving treatment. In addition, ambulatory investigations allow health care professionals to follow the progression of a patient’s condition, which can keep costs down by avoiding unnecessary medical call outs and hospital visits.

The real-time monitoring system for patients consists of vital signs sensors, a sensor network, electronic patient records, and web portable technology that calls on medical personnel when life-threatening events occur. The movement, temperature, blood pressure, and heart rate sensors are miniature and lightweight. These devices can monitor various signals, process the data for them, and integrate the wireless networks for health monitoring. The researchers have demonstrated efficacy with their integrated wireless system in terms of wireless connectivity and monitoring of vital signs of patients with COPD undergoing rehabilitation. The sensors have been programmed to send out alert signals above a certain unhealthy body temperature, below a specific heart rate, or blood pressure changes of more than 10%.

Caregiver burnout is a state of physical, emotional, and mental exhaustion that may be accompanied by a change in attitude from positive and caring to negative and unconcerned. Burnout can occur when caregivers don’t get the help they need, or if they try to do more than they are able either physically or financially. Many caregivers also feel guilty if they spend time on themselves rather than on their ill or elderly loved ones. Caregivers who are “burned out” may experience fatigue, stress, anxiety, and depression.

What is the difference between caregiver burnout and depression? If burnout manifests as depression, the caregiver might want to turn to escapist behaviors such as sex, drinking, drugs, or compulsive behaviors. Depression also might be occurring if the caregiver wants to sleep all of the time or if he or she is “too tired” to socialize or engage in activities that were previously enjoyed.

From Jo/NM to Caregivers: I thought others might find this CNN article interesting. I definitely fall into all 5 categories with…

Your physician should be consulted on all medical decisions. New procedures or drugs should not be started or stopped without such consultation. While we believe that our accumulated experience has value, and a unique perspective, you must accept it for what it is… the work of COPD patients . We vigorously encourage individuals with COPD to take an active part in the management of their disease. They do this through education and by sharing information and thoughts with their primary physician and pulmonoligist. However, medical decisions are based on complex medical principles and should be left to the medical practitioner who has been trained to diagnose and advise.

From LindaS to the COPD List: I have a question for those who use liquid 02. I got sprayed with liquid 02 trying to fill my portable tank. It got into my eyes and they have been matted in the mornings. now my vision seems clouded. Has this ever happened to you? If so what did you do about it? Do you expect it to clear up or do I need to see a doctor, an optometrist or primary doctor?

Linda was advised to seek medical attention immediately and later responded.

Dear Friends: Thank you so very much for your input on my question of splashing liquid 02 in my eyes. I contacted the doctor on call, and he said: There is nothing that can be, or needs to be done. It will only (cause) dry eyes for a time and to keep putting saline drops in my eyes. I am passing this on in case something similar happens to anyone else.

Ben/FL: Thought I would share a practice that seems to be helping me. I use a saline spray to help keep contaminants out of my sinus. The method I use is that when I spray into my nose I breath out through the nose at the same time.

The benefit I find is: I start back when ever I feel that first little tickle of something inhaled. By blowing out through the nose while spraying in I don’t draw the irritant up into the sinus passages.

This is the first year I have avoided sinus problems which, in the past, always result in chest congestion and Doctor visits. Florida had a very heavy pollen year.

In the first scientific study of its kind, shark cartilage extract, AE-941 or Neovastat, has shown no benefit as a therapeutic agent when combined with chemotherapy and radiation for patients with advanced non-small cell lung cancer, according to researchers at The University of Texas MD Anderson Cancer Center.The absence of blood vessels in cartilage as well as preclinical studies analyzing cartilage extracts have supported the hypothesis that cartilage contains inhibitors of angiogenesis. Also, shark cartilage has long intrigued the public due to the belief that the incidence of cancer in this cartilaginous fish is very rare. The study was published in the Journal of the National Cancer Institute.

Subscription to this Newsletter is free and we hope that it serves your needs. For more Newsletter information, go to

The Newsletter, like all the other endeavors of the Family of COPD Support Programs , is provided to you by COPD-Support, Inc. a non-profit member organization with IRS designation 501(c)(3). If you would like to be involved and help us provide these programs to the individuals who benefit from them, please consider joining us as a member. Further information is available at

Discovery channel has a whole bunch of games and quizzes that are pretty interesting

Create and send a congratulatory Hersey Kiss to mark that special occasion.

Extreme Camping

The Reunion

Rockin’ Chair Boogie

Until next Friday,
Joan Costello, Editor

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