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Suspected human case of 'Mad cow disease' in Cali Colombia

Posted May 22 2013 10:00am
Lunes 20 de Mayo de 2013 - 03:44 PM


 Posible primer caso de enfermedad de ‘vacas locas’ en Colombia


 Una paciente internada en un centro asistencial de Cali podría convertirse en el primer caso de la ‘enfermedad de las vacas locas' en Colombia, de acuerdo con los exámenes especializados que le fueron practicados por el Instituto de Referencia Andino.



 Martha Pérez, hermana de paciente de 61 años, aseguró que “nos llegaron los exámenes que se le han hecho a mi hermana diciendo que ella tiene la peste de las ‘vacas locas’. Las primeras personas que han estado revisando esos exámenes dicen que es el primer caso en Colombia, y que si ella está contagiada es por la carne y la leche que consumió en el país”.





No obstante, fuentes del Ministerio de Salud consultadas por Colprensa descartaron de plano la presencia en el país de esta enfermedad, hasta ahora solo detectada en algunos países de Europa, y advirtieron que el tema “no debe ser motivo de preocupación”.


 Sin embargo, dijeron que el tema está siendo “revisado” y que esta tarde “habrá un pronunciamiento oficial” sobre el tema.


 Hasta el momento, la clínica de la capital del Valle del Cauca, en donde permanece recluida la paciente, no ha hecho comentarios sobre el estado de salud de la mujer afectada.


 La ‘enfermedad de las vacas locas’, cuyo nombre científico es Creutzfeldt-Jakob (ECJ), aún no tiene certezas sobre el modo en cómo se contrae, pero los recientes estudios apuntan a que se debe al consumo de carne contaminada con la enfermedad, o por transfusiones de sangre.


 Pérez dijo que su hermana nunca ha viajado a Europa (continente donde ya se han reportado algunos casos) y que si, en efecto, se contagió, fue por lo que consumió en Colombia.


 “Ella no puede hablar porque está como en estado de coma, no ha ido a Europa, supuestamente eso solo se da allá, pero aquí en Suramérica ella fue hace como un año a Guayaquil”, aseguró.


Y contó que su familiar comenzó a sentirse mal: en principio presentó entumecimiento de los músculos de las piernas acompañado de intenso dolor; luego empezó a presentar oscurecimiento de la visión y pérdida del equilibrio. A todo ello se agregan síntomas como vómito, desorientación y mareo, por lo que fue llevada de urgencias al médico.


 “Aquí en Colombia nos dijeron que ella estaba sana de todo. En Bogotá y Medellín, todo salía negativo, no le salía nada. Decidimos mandar el caso a Estados Unidos para que lo estudiaran allá y nos llegaron los resultados de estos exámenes en los que dice que ella tiene la peste de las ‘vacas locas’”, agregó Martha Pérez.


 En lo últimos años se han presentado casos de estos en Gran Bretaña, Portugal, Irlanda y Francia, así como otros casos esporádicos en otros países europeos, en los cuales los pacientes han muerto por deficiencias en sus sistema nervioso.


Recientemente el equipo Analítico de Protección de la Salud del Gobierno del Reino Unido indicó que algo más de mil británicos podrían morir en ese país a causa de la enfermedad. El informe también advirtió que algunos expertos estiman que 30 mil ciudadanos de esa nación podrían ser portadores de la enfermedad.





Publicada por
 COLPRENSA





  http://www.vanguardia.com/actualidad/colombia/208988-posible-primer-caso-de-enfermedad-de-vacas-locas-en-colombia







 CREUTZFELDT-JAKOB DISEASE - COLOMBIA: VARIANT CJD SUSPECTED




***********************************************************


A ProMED-mail post



http://www.promedmail.org




ProMED-mail is a program of the
International Society for Infectious Diseases

http://www.isid.org



Date: Mon 20 May 2013
Source: La Vanguardia, Colprensa report [in Spanish, trans.
Sr.Tech.Ed.MJ, edited]

http://www.vanguardia.com/actualidad/colombia/208988-posible-primer-caso-de-enfermedad-de-vacas-locas-en-colombia





 Suspected human case of 'Mad cow disease'



----------------------------------------




 A 61-year-old woman who was admitted to a hospital in Cali could be the 1st case of 'mad cow disease' [variant Creutzfeldt-Jakob disease (vCJD)] in Colombia, according to specialized tests performed by the Instituto de Referencia Andino [laboratory in Colombia].



 The patient's sister said, "The results of tests done on my sister say she has 'mad cow disease'. The persons who reviewed the tests initially say it is the 1st case in Colombia, and if she is infected it would have been through meat and milk consumed in the country."



 However, sources from the Ministry of Health consulted by Colprensa ruled out the presence of this disease in the country and warned that this "should not be a matter for concern." Nonetheless, they said the issue is being "reviewed" and "an official statement" on the subject will be issued this afternoon [20 May 2013]. So far, the clinic in the capital of Valle del Cauca, where the patient remains hospitalized, has not commented on her condition.



 How 'mad cow disease', whose scientific name is [variant Creutzfeldt-Jakob disease (vCJD)], is contracted has not been fully ascertained, but recent studies suggest that it is through consumption of meat contaminated with the [the prion causing the disease], or through blood transfusions.



 The patient's sister said the woman has never traveled to Europe (where cases have been reported) and if, in fact she became infected, it had to be through something she ate in Colombia. "She can not speak because she is in a comatose state, but she has not traveled to Europe where supposedly the disease only occurs, but about a year ago she went to Guayaquil (Ecuador]," she said.



 The woman said initially her sister presented numbness of the muscles of the legs accompanied by intense pain, followed by dimness of vision and loss of balance, in addition to other symptoms such as vomiting, disorientation, and dizziness, for which she was taken to the emergency service.



 "In Colombia we were told she was completely healthy. In Bogota and Medellin all tests were negative. We decided to send the case to the USA for further exploration and the results we received said she has 'mad cow disease'."



 In recent years cases have been reported in Britain, Portugal, Ireland, and France, and sporadic cases have been reported in other European countries, in which patients have died from damage to their nervous systems.



 The UK Health Protection Agency recently indicated that more than 1000 Britons could die in the UK because of the disease. The report also warned that some experts estimate that 30 000 citizens of that country could be carriers of the disease.



 --



 Communicated by: ProMED-mail from HealthMap alerts


  promed@promedmail.org



[CJD (Creutzfeldt-Jakob Disease) is a rare illness and is one of a group of neurological diseases called prion diseases, which affect [both] humans and animals. Prion diseases exist in different forms, all of which are progressive, currently untreatable and ultimately fatal. Their name arises because they are associated with an alteration in a naturally occurring protein: the prion protein.



CJD was first described in 1920. The commonest form is called sporadic CJD and occurs worldwide, causing around 1-2 deaths per million population per year. A new form of CJD (called variant Creutzfeldt-Jacob disease, vCJD) linked to bovine spongiform encephalopathy (BSE) in cattle was identified in 1996. There are also inherited forms of human prion disease linked to mutations of the prion protein gene and cases caused by infection via medical or surgical treatments (iatrogenic CJD).



Variant Creutzfeldt-Jakob disease is a rare and fatal human neurodegenerative condition which is classified as a Transmissible Spongiform Encephalopathy (TSE) because of its ability to be transmitted and the characteristic spongy degeneration of the brain that it causes. vCJD was first described in the United Kingdom in March 1996 and has been linked with exposure to a TSE of cattle called Bovine Spongiform Encephalopathy (BSE), also known as Classical BSE1, which was first reported in the United Kingdom in 1986. In contrast to the traditional forms of CJD, vCJD has affected younger patients (median age at death of 28 years, as opposed to 68 years) and has a relatively longer duration of illness (median of 14 months as opposed to 4.5 months). vCJD was associated with the consumption of meat from BSE-infected cattle.



 From October 1996 to March 2011, 176 cases of vCJD have been reported in the United Kingdom, 25 in France, 5 in Spain, 4 in Ireland, 3 each in the Netherlands and the United States of America (USA), 2 each in Canada, Italy and Portugal, and one each in Japan, Saudi Arabia and Taiwan. The number of cases of vCJD in the United Kingdom peaked in 2000 with 28 deaths and then gradually declined. No cases have been confirmed in the UK since 2011.



It is likely that the patient in Colombia has contracted the sporadic form of CJD, or more rarely is expressing a genetic form of the disease. A conclusive diagnosis will require precise molecular characterisation of the patient's prion protein, and is a matter of considerable general interest. - Mod.CP.




 A HealthMap/ProMED-mail map can be accessed at:






 A HealthMap/ProMED-mail map can be accessed at:





  http://healthmap.org/r/1l0z


 Visit ProMED-mail's web site at http://www.promedmail





http://www.promedmail.org/direct.php?id=20130521.1729226






Monday, October 10, 2011


EFSA Journal 2011 The European Response to BSE: A Success Story


snip...


EFSA and the European Centre for Disease Prevention and Control (ECDC) recently delivered a scientific opinion on any possible epidemiological or molecular association between TSEs in animals and humans (EFSA Panel on Biological Hazards (BIOHAZ) and ECDC, 2011). This opinion confirmed Classical BSE prions as the only TSE agents demonstrated to be zoonotic so far but the possibility that a small proportion of human cases so far classified as "sporadic" CJD are of zoonotic origin could not be excluded. Moreover, transmission experiments to non-human primates suggest that some TSE agents in addition to Classical BSE prions in cattle (namely L-type Atypical BSE, Classical BSE in sheep, transmissible mink encephalopathy (TME) and chronic wasting disease (CWD) agents) might have zoonotic potential.



snip...



http://www.efsa.europa.eu/en/efsajournal/pub/e991.htm?emt=1



http://www.efsa.europa.eu/en/efsajournal/doc/e991.pdf




Thursday, August 12, 2010



Seven main threats for the future linked to prions



First threat



The TSE road map defining the evolution of European policy for protection against prion diseases is based on a certain numbers of hypotheses some of which may turn out to be erroneous. In particular, a form of BSE (called atypical Bovine Spongiform Encephalopathy), recently identified by systematic testing in aged cattle without clinical signs, may be the origin of classical BSE and thus potentially constitute a reservoir, which may be impossible to eradicate if a sporadic origin is confirmed.



***Also, a link is suspected between atypical BSE and some apparently sporadic cases of Creutzfeldt-Jakob disease in humans. These atypical BSE cases constitute an unforeseen first threat that could sharply modify the European approach to prion diseases.



Second threat



snip...



http://www.neuroprion.org/en/np-neuroprion.html





http://bse-atypical.blogspot.com/2013/02/the-many-faces-of-mad-cow-disease.html







Sunday, May 19, 2013


CJD BLOOD SCREENING, DONORS, AND SILENT CARRIERS House of Commons Written Answers 16 May 2013

  http://creutzfeldt-jakob-disease.blogspot.com/2013/05/cjd-blood-screening-donors-and-silent.html






 Monday, May 6, 2013

 Warning of mad cow disease threat to blood transfusions

  http://transmissiblespongiformencephalopathy.blogspot.com/2013/05/warning-of-mad-cow-disease-threat-to.html







Tuesday, April 30, 2013

 Mad cow infected blood 'to kill 1,000’

  http://vcjdtransfusion.blogspot.com/2013/04/mad-cow-infected-blood-to-kill-1000.html







Friday, June 29, 2012


Highly Efficient Prion Transmission by Blood Transfusion

  http://transmissiblespongiformencephalopathy.blogspot.com/2012/06/highly-efficient-prion-transmission-by.html







Tuesday, March 5, 2013


Use of Materials Derived From Cattle in Human Food and Cosmetics; Reopening of the Comment Period FDA-2004-N-0188-0051 (TSS SUBMISSION)

 FDA believes current regulation protects the public from BSE but reopens comment period due to new studies

  http://transmissiblespongiformencephalopathy.blogspot.com/2013/03/use-of-materials-derived-from-cattle-in_6452.html






Tuesday, March 05, 2013


A closer look at prion strains Characterization and important implications Prion
 7:2, 99–108; March/April 2013; © 2013 Landes Bioscience

  http://creutzfeldt-jakob-disease.blogspot.com/2013/03/a-closer-look-at-prion-strains.html






 Sunday, February 10, 2013


Creutzfeldt-Jakob disease (CJD) biannual update (February 2013) Infection report/CJD

  http://creutzfeldt-jakob-disease.blogspot.com/2013/02/creutzfeldt-jakob-disease-cjd-biannual.html





 Tuesday, May 7, 2013

 Proteinopathies, a core concept for understanding and ultimately treating degenerative disorders?

  http://proteinopathies.blogspot.com/2013/05/proteinopathies-core-concept-for.html







Friday, April 19, 2013


APHIS 2013 Stakeholder Meeting (March 2013) BSE TSE PRION

  http://madcowusda.blogspot.com/2013/04/aphis-2013-stakeholder-meeting-march.html







Tuesday, November 02, 2010


BSE - ATYPICAL LESION DISTRIBUTION (RBSE 92-21367) statutory (obex only) diagnostic criteria CVL 1992


http://bse-atypical.blogspot.com/2010/11/bse-atypical-lesion-distribution-rbse.html






 Saturday, December 15, 2012


Bovine spongiform encephalopathy: the effect of oral exposure dose on attack rate and incubation period in cattle -- an update 5 December 2012


http://bse-atypical.blogspot.com/2012/12/bovine-spongiform-encephalopathy-effect.html







Thursday, February 14, 2013


The Many Faces of Mad Cow Disease Bovine Spongiform Encephalopathy BSE and TSE prion disease


http://bse-atypical.blogspot.com/2013/02/the-many-faces-of-mad-cow-disease.html






 TSS
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