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Minimise transmission risk of CJD and vCJD in healthcare settings

Posted Sep 26 2013 10:36am
Guidance

Minimise transmission risk of CJD and vCJD in healthcare settings


Guidance on prevention of CJD and vCJD by Advisory Committee on Dangerous Pathogens' Transmissible Spongiform Encephalopathy (ACDP TSE) Risk Management Subgroup.

Documents

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If you use assistive technology and need a version of this document in a more accesible format please email publications@dh.gsi.gov.uk quoting your address, telephone number along with the title of the publication ("Annex A2: Distribution of infectivity in animal tissue and body fluids").
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Detail

This guidance produced by the Advisory Committee on Dangerous Pathogens’ Transmissible Spongiform Encephalopathy ( ACDP TSE) Risk Management Subgroup aims to help minimise the risk of transmission of CJD and vCJD in healthcare and other work settings.


Published:
27 November 2012
Updated:
13 May 2013
+ full page history

13 May 2013 12:10
Updated version of Annex J on Presurgical Assessment
27 November 2012 00:00
First published.
Organisation:
Department of Health



https://www.gov.uk/government/publications/guidance-from-the-acdp-tse-risk-management-subgroup-formerly-tse-working-group





Sunday, September 08, 2013

Iatrogenic Creutzfeldt-Jakob disease via surgical instruments and decontamination possibilities for the TSE prion

http://creutzfeldt-jakob-disease.blogspot.com/2013/09/iatrogenic-creutzfeldt-jakob-disease.html



 

Article in Press


 

Cleaning, disinfection and sterilization of surface prion contamination

 

G. McDonnell Affiliations STERIS Corporation, Mentor, Ohio, USA Corresponding Author InformationCorresponding author. Address: STERIS Corporation, 5960 Heisley Road, Mentor, OH 44060, USA. Tel.: +1 440 392 7118. email address, C. Dehen Affiliations CEA, Institute of Emerging Diseases and Innovative Therapies (iMETI), Division of Prions and Related Diseases (SEPIA), Fontenay-aux-Roses, France , A. Perrin Affiliations CEA, Institute of Emerging Diseases and Innovative Therapies (iMETI), Division of Prions and Related Diseases (SEPIA), Fontenay-aux-Roses, France , V. Thomas Affiliations STERIS, CEA, Fontenay-aux-Roses, France , A. Igel-Egalon Affiliations CEA, Institute of Emerging Diseases and Innovative Therapies (iMETI), Division of Prions and Related Diseases (SEPIA), Fontenay-aux-Roses, France STERIS, CEA, Fontenay-aux-Roses, France , P.A. Burke Affiliations STERIS Corporation, Mentor, Ohio, USA , J.P. Deslys Affiliations CEA, Institute of Emerging Diseases and Innovative Therapies (iMETI), Division of Prions and Related Diseases (SEPIA), Fontenay-aux-Roses, France , E. Comoy Affiliations CEA, Institute of Emerging Diseases and Innovative Therapies (iMETI), Division of Prions and Related Diseases (SEPIA), Fontenay-aux-Roses, France

 

Received 3 October 2012; accepted 27 August 2013. published online 25 September 2013. Accepted Manuscript

 

Abstract PDF

 

Summary Background

 

Prion contamination is a risk during device reprocessing, being difficult to remove and inactivate. Little is known of the combined effects of cleaning, disinfection and sterilization during a typical reprocessing cycle in clinical practice.

 

Aim

 

To investigate the combination of cleaning, disinfection and/or sterilization on reducing the risk of surface prion contamination.

 

Methods

 

In vivo test methods were used to study the impact of cleaning alone and cleaning combined with thermal disinfection and high- or low-temperature sterilization processes. A standardized test method, based on contamination of stainless steel wires with high titres of scrapie-infected brain homogenates, was used to determine infectivity reduction.

 

Findings

 

Traditional chemical methods of surface decontamination against prions were confirmed to be effective, but extended steam sterilization was more variable. Steam sterilization alone reduced the risk of prion contamination under normal or extended exposure conditions, but did show significant variation. Thermal disinfection had no impact in these studies. Cleaning with certain defined formulations in combination with steam sterilization can be an effective prion decontamination process, in particular with alkaline formulations. Low-temperature, gaseous hydrogen peroxide sterilization was also confirmed to reduce infectivity in the presence and absence of cleaning.

 

Conclusion

 

Prion decontamination is affected by the full reprocessing cycle used on contaminated surfaces. The correct use of defined cleaning, disinfection and sterilization methods as tested in this report in the scrapie infectivity assay can provide a standard precaution against prion contamination.

 

Keywords: Cleaning, Disinfection, Prion, Reprocessing, Sterilization

 

 


 

 

  Inactivation of the TSE Prion disease
 
 
Chronic Wasting Disease CWD, and other TSE prion disease, these TSE prions know no borders.
 
these TSE prions know no age restrictions.
 
The TSE prion disease survives ashing to 600 degrees celsius, that’s around 1112 degrees farenheit.
 
you cannot cook the TSE prion disease out of meat.
 
you can take the ash and mix it with saline and inject that ash into a mouse, and the mouse will go down with TSE.
 
Prion Infected Meat-and-Bone Meal Is Still Infectious after Biodiesel Production as well.
 
the TSE prion agent also survives Simulated Wastewater Treatment Processes.
 
IN fact, you should also know that the TSE Prion agent will survive in the environment for years, if not decades.
 
you can bury it and it will not go away.
 
The TSE agent is capable of infected your water table i.e. Detection of protease-resistant cervid prion protein in water from a CWD-endemic area.
 
it’s not your ordinary pathogen you can just cook it out and be done with. that’s what’s so worrisome about Iatrogenic mode of transmission, a simple autoclave will not kill this TSE prion agent.
 
 
 
Sunday, September 08, 2013
 
Iatrogenic Creutzfeldt-Jakob disease via surgical instruments and decontamination possibilities for the TSE prion
 
 
 
 
Wednesday, September 25, 2013
 
Cleaning, disinfection and sterilization of surface prion contamination
 
 
 
 
Friday, August 16, 2013
 
*** Creutzfeldt-Jakob disease (CJD) biannual update August 2013 U.K. and Contaminated blood products induce a highly atypical prion disease devoid of PrPres in primates
 
 
 
Sunday, August 11, 2013
 
Creutzfeldt-Jakob Disease CJD cases rising North America updated report August 2013
 
*** Creutzfeldt-Jakob Disease CJD cases rising North America with Canada seeing an extreme increase of 48% between 2008 and 2010
 
 
 
 
Tuesday, September 17, 2013
 
USAHA 116TH ANNUAL MEETING October 18 – 24, 2012 CWD, Scrapie, BSE, TSE prion (September 17, 2013)
 
 
 
 
Monday, September 02, 2013
 
Atypical BSE: role of the E211K prion polymorphism
 
Research Project: TRANSMISSION, DIFFERENTIATION, AND PATHOBIOLOGY OF TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES
 
Location: Virus and Prion Research Unit
 
 
 
 
Sunday, September 1, 2013
 
Evaluation of the Zoonotic Potential of Transmissible Mink Encephalopathy
 
We previously described the biochemical similarities between PrPres derived from L-BSE infected macaque and cortical MM2 sporadic CJD: those observations suggest a link between these two uncommon prion phenotypes in a primate model (it is to note that such a link has not been observed in other models less relevant from the human situation as hamsters or transgenic mice overexpressing ovine PrP [28]). We speculate that a group of related animal prion strains (L-BSE, c-BSE and TME) would have a zoonotic potential and lead to prion diseases in humans with a type 2 PrPres molecular signature (and more specifically type 2B for vCJD)
 
snip...
 
Together with previous experiments performed in ovinized and bovinized transgenic mice and hamsters [8,9] indicating similarities between TME and L-BSE, the data support the hypothesis that L-BSE could be the origin of the TME outbreaks in North America and Europe during the mid-1900s.
 
 
 
 
Wednesday, September 25, 2013
 
Presence of subclinical infection in gene-targeted human prion protein transgenic mice exposed to atypical BSE
 
 


something I must add, that always brings this iatrogenic CJD home for me. this old study, and remember, all iatrogenic CJD is, is sporadic CJD, until the route and source of the iatrogenic event took place is confirmed and documented. this rarely happens due to incubation period. ...just saying.



> 1: J Neurol Neurosurg Psychiatry 1994 Jun;57(6):757-8
>
>
> Transmission of Creutzfeldt-Jakob disease to a chimpanzee by
> electrodes contaminated during neurosurgery.
>
> Gibbs CJ Jr, Asher DM, Kobrine A, Amyx HL, Sulima MP, Gajdusek DC.
>
> Laboratory of Central Nervous System Studies, National Institute of
> Neurological Disorders and Stroke, National Institutes of Health,
> Bethesda, MD 20892.
>
> Stereotactic multicontact electrodes used to probe the cerebral
> cortex of a middle aged woman with progressive dementia were
> previously implicated in the accidental transmission of
> Creutzfeldt-Jakob disease (CJD) to two younger patients. The
> diagnoses of CJD have been confirmed for all three cases. More than
> two years after their last use in humans, after three cleanings and
> repeated sterilisation in ethanol and formaldehyde vapour, the
> electrodes were implanted in the cortex of a chimpanzee. Eighteen
> months later the animal became ill with CJD. This finding serves to
> re-emphasise the potential danger posed by reuse of instruments
> contaminated with the agents of spongiform encephalopathies, even
> after scrupulous attempts to clean them.
>
> PMID: 8006664 [PubMed - indexed for MEDLINE]
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8006664&dopt=Abstract
>
>




new url ;



http://www.ncbi.nlm.nih.gov/pubmed/8006664



full text ;


http://jnnp.bmj.com/content/57/6/757.long


 
 
 
kind regards,
terry
 

 
 
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