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MAD COW FEED RECALL 2009 Product may have contained prohibited materials (208,820 LBS. THAT COULD CONTAINED PRIONS...TSS) withou

Posted Aug 27 2009 10:18pm
Subject: 2009 Product may have contained prohibited materials (THAT COULD CONTAIN PRIONS...TSS) without cautionary statement on the label

PRODUCT Bulk Whole Barley, Recall # V-256-2009

CODE No code or lot number.

RECALLING FIRM/MANUFACTURER Mars Petcare US, Clinton, OK, by telephone on May 21, 2009. Firm initiated recall is complete.

REASON Product may have contained prohibited materials without cautionary statement on the label.

VOLUME OF PRODUCT IN COMMERCE 208,820 pounds

DISTRIBUTION TX END OF ENFORCEMENT REPORT FOR AUGUST 26, 2009

###

http://www.fda.gov/Safety/Recalls/EnforcementReports/ucm180348.htm



Greetings,

I saw this latest mad cow feed warning letter and notice a few changes. thought it looked a little fishy, so looking further i find it seems that now the FDA et al could not say mad cow or BSE, even if they had a mouth full of it, this is exactly what this warning letter recall is about, recalling potential mad cow feed, that might contain prions, that might get fed to cattle or other ruminants. this is the poorest i have seen yet on a warning letter with lack of information. compare it to the feed ban recall warning letter at the bottom. ALSO, This violator violations were so bad, they required an OAI on 05/28/2009, but you would not have noticed this by it's warning letter. SO, you have 208,820 pounds more of suspect mad cow feed IN COMMERCE, feeding to pets, or maybe cattle, who knows, no warning label on it. NOTHING HAS CHANGED, IT'S ALL STILL VOLUNTARY BSe. ...

I reported this back on Saturday, June 13, 2009 ;

DAL-DO 3007064862 Mars Petcare US #1 Mars Road Clinton OK 73601 OPR PF HP 05/28/2009 OAI Y

snip...

An OAI inspection classification occurs when significant objectionable conditions or practices were found and regulatory sanctions are warranted in order to address the establishment's lack of compliance with the regulation. An example of an OAI inspection classification would be findings of manufacturing procedures insufficient to ensure that ruminant feed is not contaminated with prohibited material. Inspections classified with OAI violations will be promptly re-inspected following the regulatory sanctions to determine whether adequate corrective actions have been implemented

snip...

http://madcowfeed.blogspot.com/2009/06/bse-feed-violations-usa-update-from.html



I SUPPOSE, IF ONE WAITS LONG ENOUGH BEFORE ANNOUNCING RECALL, ONE MIGHT HOPE ALL MAD COW FEED IS FED OUT INTO COMMERCE $$$

#70

GUIDANCE FOR INDUSTRY

SMALL ENTITIES COMPLIANCE GUIDE FOR FEEDERS OF RUMINANT ANIMALS WITHOUT ON-FARM FEED MIXING OPERATIONS

(This version of the guidance replaces the version that was made available in February 1998. This guidance document has been revised to update contact information and provide new requirements regarding the use of tallow in ruminant feed.)

Submit comments on this guidance at any time. Submit written comments to the Division of Dockets Management (HFA-305), Food and Drug Administration, 5630 Fishers Lane, Room 1061, Rockville, MD 20852. Comments may also be submitted electronically on the Internet at http://www.regulations.gov .

For questions regarding this guidance document, contact Shannon Jordre, Division of Compliance (HFV-230), U.S. Food and Drug Administration, Center for Veterinary Medicine, 7519 Standish Place, MPN-4, Rockville, MD 20855, (240) 276-9229.

Additional copies of this guidance document may be requested from the Communications Staff, HFV-12, Center for Veterinary Medicine, U.S. Food and Drug Administration, 7519 Standish Place, Rockville, MD 20855, and may be viewed on the Internet at

http://www.fda.gov/AnimalVeterinary/default.htm .



U.S. Department of Health and Human Services Food and Drug Administration Center for Veterinary Medicine July 13, 2009

CONTAINS NON-BINDING RECOMMENDATIONS

Guidance for Industry

SMALL ENTITIES COMPLIANCE GUIDE FOR FEEDERS OF RUMINANT ANIMALS WITHOUT ON-FARM FEED MIXING OPERATIONS1

This guidance document represents the Food and Drug Administration’s (FDA’s) current thinking on this topic. It does not create or confer any rights for or on any person and does not operate to bind FDA or the public. You can use an alterative approach if the approach satisfies the requirements of the applicable statutes and regulations. If you want to discuss an alternative approach, contact the FDA staff responsible for implementing this guidance. If you cannot identify the appropriate FDA staff, call the appropriate number listed on the title page of this guidance.

Introduction

On April 25, 2008, FDA published a final rule in the Federal Register, entitled “Substances Prohibited from Use in Animal Food or Feed” (73 FR 22719). See also 73 FR 18626; April 24, 2009. This final rule established a new regulation at 21 CFR 589.2001 entitled, “Cattle Materials Prohibited in Animal Food or Feed to Prevent the Transmission of Bovine Spongiform Encephalopathy”. 21 CFR 589.2001 prohibits the use of certain cattle materials in the feed of all animals and is aimed primarily at rendering operations. This new rule also amended the previously existing BSE regulation, 21 CFR 589.2000 entitled, “Animal Proteins Prohibited in Ruminant Feed“, which addresses only the feeding of ruminant animals.

The Food and Drug Administration (FDA) has prepared this Small Entities Compliance Guide in accordance with section 212 of the Small Business Regulatory Enforcement Fairness Act of 1996. (Public Law 104-121). This guidance document represents the agency's current thinking on compliance with the regulation 21 CFR 589.2000 "Animal Proteins Prohibited in Ruminant Feed", as amended during the recent rule-making process, and how the regulation impacts livestock producers feeding ruminant animals.

FDA’s guidance documents, including this guidance, do not establish legally enforceable responsibilities. Instead, guidances describe the Agency’s current thinking on a topic and should be viewed only as recommendations, unless specific regulatory or statutory requirements are cited. The use of the word “should” in Agency guidances means that something is suggested or recommended, but not required.

What Is The Purpose And Scope Of This Regulation, 21 CFR 589.2000?

This regulation is designed to prevent the establishment and amplification of Bovine Spongiform Encephalopathy (BSE), sometimes referred to as “Mad Cow Disease,” through animal feed. The

1 This guidance has been prepared by the Office of Surveillance and Compliance in the Center for Veterinary Medicine.

2

CONTAINS NON-BINDING RECOMMENDATIONS

regulation prohibits the use of certain proteins derived from mammalian tissue in feeding ruminant animals. An example is meat and bone meal derived from cattle. However, certain products are exempt from this regulation.

• The following protein products derived from mammals are exempt
• Blood and blood products

• Gelatin

• Milk products (milk and milk proteins)

• Pure porcine (pork) or pure equine (horse) protein products

• Inspected meat products, such as plate waste, which have been cooked and offered for human food and further heat processed for animal feed

• The following nonmammalian protein products are exempt
• Poultry

• Marine (fish)

• Vegetable

• The following products are also exempt because they are not protein or tissue
• Grease

• Tallow that contains no more than 0.15% insoluble impurities2

• Fat3

• Amino acids

• Vegetable oil

• Dicalcium phosphate

We refer to the exempted products throughout this guide as “nonprohibited material.” We refer to all mammalian protein that is not exempted as “prohibited material.”

Prohibited material and/or feeds containing prohibited material cannot be fed to ruminant animals. “Ruminant animals” are any animals with a four-chambered stomach including cattle, sheep, goats, buffalo, elk, and deer.

Is My Operation Affected By 21 CFR 589.2000?

• This regulation applies to livestock feeding operations that feed ruminants. The regulation applies to "establishments and individuals that are responsible for feeding ruminants" to make it clear that all responsible persons, in both large and small feeding operations, are subject to the regulation.

• Examples include dairies, cattle feed lots, calf and lamb raising operations, cattle, sheep, and goat grazing operations.

2 Tallow is defined by 21 CFR 589.2001(b)(5) as the rendered fat of cattle. Tallow that contains more that 0.15% insoluble impurities is considered to be an animal protein prohibited in ruminant feed in 21 CFR 589.2000(a)(1). Such tallow should be labeled with the cautionary statement “Do Not Feed to Cattle or Other Ruminants.”

3 Excludes tallow that contains more than 0.15% insoluble impurities.

3

CONTAINS NON-BINDING RECOMMENDATIONS

• If a feed product intended for ruminants contains animal protein, the protein can consist only of nonprohibited material.

• The Association of American Feed Control Officials (AAFCO) has identified the following ingredients listed in its Official Publication as prohibited material
• Meat

• Meat By-Products

• Animal Liver

• Dried Meat Solubles

• Fleshings Hydrolysate

• Meat Meal

• Meat and Bone Meal

• Animal By-Product Meal

• Meat Meal Tankage

• Meat and Bone Meal Tankage

• Hydrolyzed Leather Meal

• Hydrolyzed Hair

• Glandular Meal and Extracted Glandular Meal

• Stock/Broth

• Animal Digest

• Cooked Bone Marrow

• Leather Hydrolysate

• Meat Protein Isolate

• Mechanically Separated Bone Marrow

• Unborn Calf Carcasses

• Bone Meal, cooked

• Bone Meal, steamed

• Dehydrated Garbage

• Dehydrated Food-Waste

• Salvage Pet Food

• Distressed Pet Food

Feed and feed ingredients not containing animal proteins are not subject to the regulation.

• Persons who feed prohibited material to ruminants would be subject to regulatory action under the Federal Food, Drug, and Cosmetic Act. Regulatory action could include seizure of inventory, injunction against feeding prohibited material to ruminants, or prosecution.

Note: If you mix your own feed for your ruminant animals, you are subject to additional requirements. Consult the “Small Entities Compliance Guide for Feeders of Ruminant Animals with On-Farm Feed Mixing Operations,” FDA Guidance for Industry 69.

How Do I Comply With 21 CFR 589.2000?

4

CONTAINS NON-BINDING RECOMMENDATIONS

1. Do not feed products labeled with the caution statement “Do not feed to cattle or other ruminants” to your ruminant animals4.

2. Maintain copies of all purchase invoices for ALL feeds received that contain animal protein.

3. Maintain copies of labeling for ALL feeds received containing animal protein products.

4. Keep invoices and labeling available for inspection and copying.

5. Maintain the records for a minimum of one year.

What Other Information Do I Need To Know To Help Me Comply With 21 CFR 589.2000?

• Renderers, protein blenders, and feed manufacturers are required to label products containing prohibited materials with the cautionary statement Do not feed to cattle or other ruminants.

• If you intend to feed only ruminant animals, products with this caution statement should not be available for use in your operation. If the feed does not bear the caution statement but you suspect that it contains prohibited material, do not use it until you are sure that it does not contain such materials.

• If you intend to use a feed containing prohibited material for nonruminant animals, take steps to ensure that the feed will not be fed to ruminants.

• Labeling And Record Keeping

• For bulk shipments it is common practice to provide labeling information on the invoice. In such cases, retaining the invoice is sufficient documentation.

• If the only labeling for a bulk product is on a placard, the placard for each shipment should be retained.

• Feed may also be received in bags or other containers that have attached labeling. In those instances, the labeling should be removed and retained. However, maintenance of only one such labeling piece from each shipment that represents a different product is necessary.

• If the labeling cannot be removed from the bag or other container, it is acceptable to retain a representative bag or a transposed copy of the labeling information from a container that cannot feasibly be stored.

• The records should be legible and readily retrievable.

4 If the product label bears the “Do Not Feed to Animals” statement, take steps to ensure that it is not fed to animals. This product should not have been introduced into the animal feed chain because it is prohibited from use in any animal feed by another rule titled “SUBSTANCES PROHIBITED FROM USE IN ANIMAL FOOD OR FEED” and codified in 21 CFR 589.2001. This rule published on April 25, 2008, with an effective date of April 27, 2009.

5

CONTAINS NON-BINDING RECOMMENDATIONS

• The one year requirement for maintenance of records means one year from the date of the receipt of the product.

• Inspections

• On-farm inspections will be limited but will be needed on a selective basis to trace prohibited material to verify that it is not being shipped to ruminant producers and fed to ruminant animals. For example, on-farm inspection might be necessary as a follow up to a feed mill inspection, to verify that feed not labeled with the cautionary statement is in fact being fed to nonruminant animals.

http://www.fda.gov/downloads/AnimalVeterinary/GuidanceComplianceEnforcement/GuidanceforIndustry/UCM052385.pdf



FDA GUIDANCE FOR INDUSTRY 67 This guide replaces those parts of Guidance for Industry 60, June 17, 1997, that applied to renderers.

http://www.fda.gov/downloads/AnimalVeterinary/GuidanceComplianceEnforcement/GuidanceforIndustry/ucm052381.pdf



FDA GUIDANCE FOR INDUSTRY 68 This guide replaces those parts of Guidance for Industry 60, June 17, 1997, that applied to protein blenders, feed manufacturers, and distributors. SMALL ENTITIES COMPLIANCE GUIDE FOR PROTEIN BLENDERS, FEED MANUFACTURERS, AND DISTRIBUTORS This document is intended to provide guidance for “ANIMAL PROTEINS PROHIBITED FROM USE IN RUMINANT FEED,” Title 21, Code of Federal Regulations, Part 589.2000, Effective Date: August 4, 1997.

http://www.fda.gov/downloads/AnimalVeterinary/GuidanceComplianceEnforcement/GuidanceforIndustry/ucm052382.pdf



NOTHING BUT INK ON PAPER I TELL YOU !


10,000,000+ LBS. of PROHIBITED BANNED MAD COW FEED I.E. BLOOD LACED MBM IN COMMERCE USA 2007


Date: March 21, 2007 at 2:27 pm PST

RECALLS AND FIELD CORRECTIONS: VETERINARY MEDICINES -- CLASS II

___________________________________


PRODUCT

Bulk cattle feed made with recalled Darling's 85% Blood Meal, Flash Dried, Recall # V-024-2007

CODE

Cattle feed delivered between 01/12/2007 and 01/26/2007

RECALLING FIRM/MANUFACTURER

Pfeiffer, Arno, Inc, Greenbush, WI. by conversation on February 5, 2007.

Firm initiated recall is ongoing.

REASON

Blood meal used to make cattle feed was recalled because it was cross- contaminated with prohibited bovine meat and bone meal that had been manufactured on common equipment and labeling did not bear cautionary BSE statement.

VOLUME OF PRODUCT IN COMMERCE

42,090 lbs.

DISTRIBUTION

WI

___________________________________

PRODUCT

Custom dairy premix products: MNM ALL PURPOSE Pellet, HILLSIDE/CDL Prot- Buffer Meal, LEE, M.-CLOSE UP PX Pellet, HIGH DESERT/ GHC LACT Meal, TATARKA, M CUST PROT Meal, SUNRIDGE/CDL PROTEIN Blend, LOURENZO, K PVM DAIRY Meal, DOUBLE B DAIRY/GHC LAC Mineral, WEST PIONT/GHC CLOSEUP Mineral, WEST POINT/GHC LACT Meal, JENKS, J/COMPASS PROTEIN Meal, COPPINI - 8# SPECIAL DAIRY Mix, GULICK, L-LACT Meal (Bulk), TRIPLE J - PROTEIN/LACTATION, ROCK CREEK/GHC MILK Mineral, BETTENCOURT/GHC S.SIDE MK-MN, BETTENCOURT #1/GHC MILK MINR, V&C DAIRY/GHC LACT Meal, VEENSTRA, F/GHC LACT Meal, SMUTNY, A- BYPASS ML W/SMARTA, Recall # V-025-2007

CODE

The firm does not utilize a code - only shipping documentation with commodity and weights identified.

RECALLING FIRM/MANUFACTURER

Rangen, Inc, Buhl, ID, by letters on February 13 and 14, 2007. Firm initiated recall is complete.

REASON

Products manufactured from bulk feed containing blood meal that was cross contaminated with prohibited meat and bone meal and the labeling did not bear cautionary BSE statement.

VOLUME OF PRODUCT IN COMMERCE

9,997,976 lbs.

DISTRIBUTION

ID and NV

END OF ENFORCEMENT REPORT FOR MARCH 21, 2007

http://www.fda.gov/bbs/topics/enforce/2007/ENF00996.html



NEW URL

http://www.fda.gov/Safety/Recalls/EnforcementReports/2007/ucm120446.htm



Thursday, March 19, 2009 MILLIONS AND MILLIONS OF POUNDS OF MAD COW FEED IN COMMERCE USA WITH ONGOING 12 YEARS OF DENIAL NOW, WHY IN THE WORLD DO WE TO TALK ABOUT THIS ANYMORE $$$

http://madcowfeed.blogspot.com/2009/03/millions-and-millions-of-pounds-of-mad.html



Monday, August 17, 2009 FDA asked to ban poultry litter from feed AGAIN 17 Aug 2009 Ban that Poop!

http://madcowfeed.blogspot.com/2009/08/fda-asked-to-ban-poultry-litter-from.html



Saturday, June 13, 2009

Monitoring the occurrence of emerging forms of Creutzfeldt-Jakob disease in the United States 2003 revisited 2009

http://cjdusa.blogspot.com/2009/06/monitoring-occurrence-of-emerging-forms.html



SEE THE VIDEO NOW AT THE BOTTOM OF THE BLOG BELOW ;

http://creutzfeldt-jakob-disease.blogspot.com/2009/07/usa-hiding-mad-cow-disease-victims-as.html



Tuesday, August 18, 2009

BSE-The Untold Story - joe gibbs and singeltary 1999 - 2009

http://madcowusda.blogspot.com/2009/08/bse-untold-story-joe-gibbs-and.html



Sunday, August 09, 2009

CJD...Straight talk with...James Ironside...and...Terry Singeltary... 2009

http://creutzfeldt-jakob-disease.blogspot.com/2009/08/cjdstraight-talk-withjames.html



Thursday, July 10, 2008

A New Prionopathy update July 10, 2008

snip...

DOES ANYONE BESIDES ME SEE A PATTERN YET ??

Vickey Rimmer, 16, DID NOT DIE FROM nvCJD, she died from a form of sporadic CJD, whatever the hell that is. and there have been 16 year old die from sporadic CJD in the USA as well.

SIMPLY PUT, the ukbsenvcjd only theory was wrong from day one. the elderly are expendable, pets and kids are not.

Science was dictated by 'big buisness' after the Vickey Rimmer case with the ukbsenvcjd only myth.

snip...

Sporadic creutzfeldt-jakob disease in two adolescents

http://jnnp.bmj.com/cgi/content/abstract/jnnp.2006.104570v1



see full text sporadic CJD the big lie;

snip...

IT seems we have come full circle from the 'ORIGINAL 10' i.e. the 1st 10 adolescents in the UKBSEnvCJD only theory. and now we find us at the 1st 10 in USA, or is it the first 10, or the tip of the iceburg, many that went undocumented ??

lets look at the full circle, to date ;

http://cjdmadcowbaseoct2007.blogspot.com/2008/07/new-prionopathy-update-july-10-2008.html



Sunday, August 10, 2008 A New Prionopathy OR more of the same old BSe and sporadic CJD

http://creutzfeldt-jakob-disease.blogspot.com/2008/08/new-prionopathy-or-more-of-same-old-bse.html



full text ;

http://creutzfeldt-jakob-disease.blogspot.com/2009/04/unusually-presenting-case-of-scjdthe.html



Tuesday, July 14, 2009

U.S. Emergency Bovine Spongiform Encephalopathy Response Plan Summary and BSE Red Book Date: February 14, 2000 at 8:56 am PST

WHERE did we go wrong $$$

http://madcowtesting.blogspot.com/2009/07/us-emergency-bovine-spongiform.html



Monday, June 01, 2009 Biochemical typing of pathological prion protein in aging cattle with BSE

SOMETHING TO PONDER ??

O.K. confusious asks, IF all these new atypical BSEs i.e. new strains of mad cow disease is just an 'OLD COW PRION DISEASE', why then can not the 'old human prion disease' such as the sporadic CJD, be from an 'old cow prion disease', same as the nvCJD 'young people mad cow disease' (which also happens in 74 year old), but why cannot the 'old cow prion diseases', i.e. l-BSE, h-BSE, and ibncBSE, cause the 'old people prion disease', which looks like sporadic CJD. seems that is what some of the pathology is showing ??

OH, that probably makes too much sense, and that the only answer could be that it's all just a happenstance of bad luck and or a spontaneous event, that just happens out of the clear blue sky $$$

IF this is the case, then where are all the SPONTANEOUS BSE CASES OF MAD COW DISEASE IN THE U.S.A., AND WHERE HAVE THEY BEEN BURIED IN THE USA OVER THE LAST 25 YEARS ??

http://bse-atypical.blogspot.com/2009/06/biochemical-typing-of-pathological.html



NOW, in 2009, in the USA, these fools want us to believe it's all nothing more than a Spontaneous Generation of Prion Infectivity, and or a familial hereditary mad cow strain in the USA that is BY SOME MIRACLE, not related to feed ;

H- and L-type BSE, collectively known as atypical BSE, differ from classical BSE by displaying a different disease phenotype and they have not been linked to the consumption of contaminated feed. Interestingly, the 2006 U.S. H-type atypical BSE animal had a polymorphism at codon 211 of the bovine prion gene resulting in a glutamic acid to lysine substitution (E211K).

https://ars.usda.gov/research/publications/publications.htm?SEQ_NO_115=226214



SO, by this i gather they have done transmission studies on atypical h type and l type BSE and neither can be transmitted by the oral route ??

or is this just more of the same old BSe, they don't know, but they conclude this with a crystal ball of some sort $$$


I remember this study well, and it was suppose to conclude this year 2009. However, when i ask and ask about this study, it becomes a top secret, everybody has closed lips and will not talk ;


----- Original Message -----
From: Justin Greenlee
To: Terry S. Singeltary Sr.
Sent: Friday, July 31, 2009 3:17 PM
Subject: Re: re-Research Project: Study of Atypical Bse

Sorry for the slow reply- your email got filtered by the FED spam system and I only recently checked for docked messages.

There are no transmission studies that are specifically associated with this project being conducted at the NADC. Probably the easiest way to learn a little bit more about what we’re doing is to give me a call sometime.

Justin

Justin J. Greenlee, DVM, PhD, Diplomate ACVP Virus and Prion Diseases of Livestock Research Unit National Animal Disease Center, USDA, ARS 2300 Dayton Ave, PO BOX 70 Ames, IA 50010

phone (515) 663-7191 FAX (515) 663-7458

On 6/15/09 4:30 PM, "Terry S. Singeltary Sr." < flounder9@verizon.net > wrote
re-Research Project: Study of Atypical Bse

http://www.ars.usda.gov/research/projects/projects.htm?ACCN_NO=408490



Greetings Sir,

I have been most interested in these transmission studies, and i know it is probably to early for you to say much about them. but, could you please give me an update of some kind, as to if transmission of any type occured, with any tissues and or body fluids. i suppose i am a bit anxious about these studies. ...

many thanks for your work,

kindest regards, terry


----- Original Message -----
From: Terry S. Singeltary Sr.
To: maria.caramelli@izsto.it
Sent: Friday, July 31, 2009 6:07 PM
Subject: re-Research Project: Study of Atypical Bse

Team Leader: Dr. Maria Caramelli Via Bologna 148 Torino, I- 10154, Italy Contact: Dr. Maria Caramelli Tel: +39 11 2686296 Fax: +39 11 2686360 E-mail: maria.caramelli@izsto.it Institute website: http://www.izsto.it


Hello Dr. Maria Caramelli,

A kind and warm greetings from Bacliff, Texas!

I hope you do not mind, but I thought I might write and ask you a bit on some transmission studies taking place, and any results there from. I have been most interested in human and animal TSE as a lay person, since the death of my mother to the Heidenhain Variant of Creutzfeldt Jakob Disease. The study in question is as follows ;

re-Research Project: Study of Atypical Bse

http://www.ars.usda.gov/research/projects/projects.htm?ACCN_NO=408490



_any_ help would be most appreciative ! and, if confidentiality is a problem, my lips are sealed !

many thanks for your continued work on TSEs. ...

Thank You,

with warmest regards,

I am sincerely,

Terry S. Singeltary Sr. P.O. Box 42 Bacliff, Texas USA 77518


THIS study specifically stated ;


> 3. Studies on transmissibility and tissue distribution of atypical BSE isolates in cattle and other species.



Research Project: Study of Atypical Bse Location: Virus and Prion Diseases of Livestock

Project Number: 3625-32000-086-05 Project Type: Specific Cooperative Agreement

Start Date: Sep 15, 2004 End Date: Sep 14, 2009

Objective: The objective of this cooperative research project with Dr. Maria Caramelli from the Italian BSE Reference Laboratory in Turin, Italy, is to conduct comparative studies with the U.S. bovine spongiform encephalopathy (BSE) isolate and the atypical BSE isolates identified in Italy. The studies will cover the following areas: 1. Evaluation of present diagnostics tools used in the U.S. for the detection of atypical BSE cases. 2. Molecular comparison of the U.S. BSE isolate and other typical BSE isolates with atypical BSE cases. 3. Studies on transmissibility and tissue distribution of atypical BSE isolates in cattle and other species.

Approach: This project will be done as a Specific Cooperative Agreement with the Italian BSE Reference Laboratory, Istituto Zooprofilattico Sperimentale del Piemonte, in Turin, Italy. It is essential for the U.S. BSE surveillance program to analyze the effectiveness of the U.S diagnostic tools for detection of atypical cases of BSE. Molecular comparisons of the U.S. BSE isolate with atypical BSE isolates will provide further characterization of the U.S. BSE isolate. Transmission studies are already underway using brain homogenates from atypical BSE cases into mice, cattle and sheep. It will be critical to see whether the atypical BSE isolates behave similarly to typical BSE isolates in terms of transmissibility and disease pathogenesis. If transmission occurs, tissue distribution comparisons will be made between cattle infected with the atypical BSE isolate and the U.S. BSE isolate. Differences in tissue distribution could require new regulations regarding specific risk material (SRM) removal.

http://www.ars.usda.gov/research/projects/projects.htm?ACCN_NO=408490



Amazing is it not, the USA have cattle that cannot get BSE or any other TSE by eating tainted mad cow type feed, only a sub-type of TSE that is NOT transmissible by feed of any sorts, NOT transmissible to humans in any way, and one that cannot be seen since 2006. what a wonderful place we live that these miracles can take place $$$ OH yes, i must not forget, Santa will be coming soon. ...TSS
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