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Game and Fish Begins Study to Evaluate Chronic Wasting Disease Vaccine

Posted Feb 21 2013 11:25am
Game and Fish Begins Study to Evaluate Chronic Wasting Disease Vaccine




2/19/2013




CHEYENNE - The Wyoming Game and Fish Department has begun a multi-year study at its Thorne-Williams Wildlife Research Unit (formerly Sybille) near Wheatland to evaluate the efficacy of a vaccine against chronic wasting disease.




Chronic wasting disease is a neurological disease of elk, deer, and moose. The disease appears to be invariably fatal to the animal, but it is not thought to affect humans.




The vaccine was developed in Canada by the Pan-Provincial Vaccine Enterprise (PREVENT), a partnership of three leading infectious disease centers. PREVENT works closely with academia, industry, government, and not-for-profit sectors to accelerate vaccine development so that promising vaccines can move readily into clinical development and production.




In January, researchers trapped 50 elk calves at Game and Fish’s South Park feedground (south of Jackson) and transported them to the research unit. There, calves were split into two groups. One group was vaccinated and one was an unvaccinated control group. “Previous research has demonstrated that elk will naturally contract chronic wasting disease by being housed at the unit,” said Game and Fish Chief Wildlife Veterinarian Dr. Terry Kreeger. “We predict that the vaccinated group will live longer than the control group. It’s important to understand that even if the vaccine does not provide lifelong protection from chronic wasting disease, every extra year of survival the vaccine provides will mean increased production in an affected population.”




The vaccine is administered by hand at the research unit, which would not be practical for vaccinating wild elk. However, if the vaccine is found to be effective, future research will focus on delivery methods more appropriate for wild elk, such as baits. At a minimum, an effective vaccine administered to elk raised on private ranches could greatly reduce the spread of the disease. Chronic wasting disease is thought to have been primarily spread throughout parts of the United States and Canada by the unintentional movement of infected deer and elk among private game ranches.




“We figured that research over time would start providing wildlife managers with tools that could be used to combat this disease,” said Kreeger. “This is just the start of a long journey to evaluate and perfect these tools.”




A parallel vaccine study is being conducted on deer in Colorado.




(Contact: Eric Keszler (307) 777-4594)




-WGFD-










CWD Zones Map for Positive Cases



All Species Positive & Negative (Updated with 2012 Data)









Positives by Species (Updated with 2012 Data)









Positives by Species (2009-2011)









CWD Surveillance Positive Deer



Positive Deer by Hunt Area (2012)







Positive Deer by Hunt Area (2009-2011)







Positive Deer by Hunt Area (2006-2008)








Positive Deer by Hunt Area (2003-2005)









CWD Surveillance Positive Elk



Positive Elk by Hunt Area (2012)










Positive Elk by Hunt Area (2009-2011)









Positive Elk by Hunt Area (2006-2008)









Positive Elk by Hunt Area (2003-2005)









CWD Surveillance Positive Moose



Positive Moose by Hunt Area (2006-2008)












WYOMING GAME AND FISH DEPARTMENT 2011 ANNUAL REPORT



SNIP...



CHRONIC WASTING DISEASE CWD




Chronic Wasting Disease Testing continued for Chronic Wasting Disease (CWD) in white-tailed and mule deer, elk, and moose in various locations of the state. WGFD divides the state into eight administrative regions with the goal to test 500-600 deer from each region utilizing hunter harvest, road killed, and targeted animals. Although the 2011 surveillance efforts are still underway, as of December 1st, 2,911 deer, elk, and moose samples had been analyzed. Of these, 103 tested positive for CWD, representing 79 mule deer, 14 white-tailed deer, and 10 elk. In 2005, the Department included moose in the CWD surveillance program. During FY 2011, 136 hunter-killed, 37 targeted and 18 road-killed moose were surveyed with no moose testing positive for CWD.










MOOSE DOCUMENTED WITH CWD WYOMING





Wednesday, October 24, 2012



WYOMING Deer Hunt Area 132 Near Green River Added to CWD List



10/23/2012



GREEN RIVER - Chronic wasting disease (CWD), a fatal neurological disease of deer, elk, and moose, has been discovered in deer hunt area 132.








Thursday, November 29, 2012



Wyoming Elk Hunt Area 10 Added to CWD List









Wednesday, November 16, 2011


Chronic wasting disease found in Big Horn basin deer Wyoming's deer hunt area 165








Thursday, July 08, 2010


CWD Controversy still stalking elk feedgrounds in Wyoming 2010


Greetings,


This is very serious, please notice that one of the CWD clusters is only 45 miles from ELK feeding grounds in Wyoming, the second elk feeding ground is 98 miles from CWD cluster, and the third elk feeding ground is 130 miles from the CWD cluster. Common sense tells us we need to stop those feeding grounds, if you want your Elk to survive. There is no politics or plot against the hunters or elk about it. read the science please. ...TSS


chronic wasting disease proximity to elk feedgrounds in wyoming 2009-2010









Thursday, December 30, 2010


WYOMING MULE DEER BUCK HARVESTED NEAR LYSITE TESTS POSITIVE FOR CWD December 27, 2010









Monday, December 13, 2010


WYOMING DEER AREA 119 ADDED TO CWD LIST DEER AREA 119 ADDED TO CWD LIST


11/22/2010









Friday, November 12, 2010


WHITE-TAILED BUCK HARVESTED NEAR MOORCROFT TESTS POSITIVE FOR CWD WYOMING









Sunday, October 31, 2010


TWO DEER HARVESTED NEAR GREYBULL TEST POSITIVE FOR CWD WYOMING









Wednesday, October 20, 2010


WYOMING ELK NEAR GLENDO TESTS POSITIVE FOR CWD 10/18/2010









Wednesday, November 25, 2009


CHRONIC WASTING DISEASE FOUND IN ELK AREA 35 NEAR BUFFALO









Wednesday, November 11, 2009


CHRONIC WASTING DISEASE DISCOVERED IN DEER HUNT AREA 42 WYOMING









Sunday, November 01, 2009


CWD confirmed in Johnson County Wyoming Sunday, November 1, 2009









Wednesday, October 14, 2009


Deer on western Bighorns has chronic wasting disease Shell Creek drainage Wyoming









Monday, December 22, 2008


CWD DETECTED IN ELK HUNT AREA 117 SOUTH OF SUNDANCE WYOMING









Saturday, October 18, 2008


WYOMING STAR VALLEY MOOSE TESTS POSITIVE FOR CWD









Monday, November 14, 2011


WYOMING Creutzfeldt Jakob Disease, CWD, TSE, PRION REPORTING 2011









Friday, November 09, 2012


Chronic Wasting Disease CWD in cervidae and transmission to other species









Friday, November 16, 2012


Yellowstone elk herds feeding grounds, or future killing grounds from CWD











Tuesday, February 28, 2012



newly developed injectable CWD vaccine, live rectal mucosa testing and Deer Game Farms Update newly developed injectable CWD vaccine, live rectal mucosa testing and Deer Game Farms Update




- testing is currently underway to determine the effectiveness of a newly developed injectable CWD vaccine that has shown considerable promise.




- an effective vaccine could be used to prevent CWD in game farm animals but additional study would be required to determine an effective application method in the wild.




snip...see full text ;

















Development of an oral vaccine for Chronic Wasting Disease



Principal Investigator: Scott Napper, Vaccine and Infectious Disease Organization



Co-investigators: Andrew Potter, Vaccine and Infectious Disease Organization Philip Griebel, Vaccine and Infectious Disease Organization Neil Cashman, Brain Research Centre, University of British Columbia Suresh Tikoo, Vaccine and Infectious Disease Organization Nate Osgood, Computer Sciences, University of Saskatchewan Trent Bollinger, Western College of Veterinary Medicine, University of Saskatchewan Ted Leighton, Western College of Veterinary Medicine, University of Saskatchewan Cheryl Waldner, Western College of Veterinary Medicine, University of Saskatchewan Murray Woodbury, Western College of Veterinary Medicine, University of Saskatchewan



Project Description



Members of our team have been focused on a disease specific epitope (DSE) termed YYR which is specifically exposed on PrPSc. Through optimization of the length and presentation of this epitope, as well as strategies of formulation and delivery, we have developed a first generation prion vaccine. This vaccine was developed with a priority on farmed cervids and employed strategies compatible with parenteral injection, the traditional route of vaccine delivery. This vaccine induces high-titre, PrPSc-specific immune responses in a variety of species and significantly delays the onset of disease in experimentally challenged sheep. Having validated the DSE immunotherapy concept, we are positioned to develop a second generation vaccine based upon additional, newly discovered DSE’s as well as an oral route of delivery. Oral delivery is required for vaccination of wild animals and is the preferred route for farmed cervids. Oral delivery may also offer greater protection against oral routes of infection, which is central to CWD transmission. Funding by PrioNet will enable and accelerate development of this novel tool to control Chronic Wasting Disease.



(Open Call IV)



Last Updated: 10/21/2011 4:44:47 PM










SNIP...FULL TEXT ;













Friday, August 24, 2012



Diagnostic accuracy of rectal mucosa biopsy testing for chronic wasting disease within white-tailed deer (Odocoileus virginianus) herds in North America














Friday, February 08, 2013



Behavior of Prions in the Environment: Implications for Prion Biology












Tuesday, December 18, 2012



A Growing Threat How deer breeding could put public trust wildlife at risk












Friday, November 09, 2012



*** Chronic Wasting Disease CWD in cervidae and transmission to other species












Friday, December 14, 2012



*** Susceptibility Chronic Wasting Disease (CWD) in wild cervids to Humans 2005 – December 14, 2012



















TSS
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