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Physical Health - Multiple Sclerosis

Posted Dec 20 2008 6:45pm
Status of Stem Cell Therapy for Multiple Sclerosis
About Multiple Sclerosis (MS)Multiple Sclerosis, with an incidence of 100 in 100000 in the US and Europe, is by far the most frequent neurodegenerative disease (1). MS is a chronic, demyelinating disease of the brain and spinal cord -collectively the central nervous system (CNS). Demyelination is a process of gradual destruction of the myelin sheath, that surrounds many of the axons of nerve cells (neurons), leading to axonal injury or loss and consequently severely impaired nerve signals. The disease is named for the multiple scleroses (scars or plaques) that are created on the myelinated axons. A repair mechanism - remyelination of the axons by cells known as oligodendrocytes - takes place in the early phases of disease but the reformed myelin sheaths are thinner and less effective. Repeated attacks lead to fewer effective remyelinations until a scar is built up on the damaged axon. The central nervous system should be able to recruit oligodendrocyte stem cells but something would seem to inhibit stem cells in the affected areas. To continue reading.......
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