Little is known about the relationship between chronicpain conditions and metabolic disturbances.This study involved women patients with fibromyalgia characterized by chronicpain, fatigue, and insomnia.
Patients with fibromyalgia commonly have an elevated body mass index and are physically inactive, 2 major risk factors for metabolic syndrome.
Women with fibromyalgia were 5.56 times more likely than healthy controls to have metabolic syndrome. Fibromyalgia was associated with larger waist circumference, higher glycosylated hemoglobin and serum triglyceride levels, and higher systolic and diastolic bloodpressure.
Total and low-density lipoprotein cholesterol were also significantly higher in women with fibromyalgia, although high-density lipoprotein cholesterol was in the reference range.These associations were not accounted for by age or body mass index.
Women with chronicpain from fibromyalgia are at an increased risk for metabolic syndrome, which may be associated with relatively elevated NE levels in conjunction with relatively reduced epinephrine and cortisol secretion. ( Loevinger BL. Muller D. Alonso C. Coe CL. Metabolic syndrome in women with chronicpain. Metabolism: Clinical & Experimental. 56(1):87-93, 2007 Jan).