XMRV: cause or effect of immunosuppression of Chronic Fatigue Syndrome? A look through the past retroviral link.
Posted Jul 05 2010 5:37am
RELEVANT NEWS:
The retrovirus Xenotropic Murine Leukemia Virus Related (XMRV) is a new human pathogen, and possibly the most important scientific discovery since HIV. Has been linked to prostate cancer and Chronic Fatigue Syndrome (CFS).
If confirmed by independent laboratories and the prevalence XMRV association with prostate cancer and CFS according to studies published in the prestigious journal Science, would reach 4% of world population infected, but asymptomatic at this time.
This Retroviruses, in the same family as HIV (AIDS) and HTLV (leukemia), is the third pathogenic retrovirus discovered in humans. Is known to exist for years in mice, but only recently has been discovered in humans, in tissues of patients with prostate cancer. The prostate cancer patients share with Chronic Fatigue Syndrome have altered the antiviral enzyme called RNase-L.
This is the clue that led to Whittermore Peterson Institute (WPI) to connect the two conditions, culminating his studies last October with the publication in Science of a surprising finding, was achieved by isolating the retrovirus XMRV in the nucleus of blood cells 67% of CFS patients and 3.7% of the healthy population. ( 1 - 2 ) After the publication, were improved detection methods and antibodies were found in plasma of 99% of CFS patients, while maintaining the same percentage in the healthy population.
These results have moved scientists around the world to run additional studies that answer the important questions that arise now: modes of transmission of the retrovirus that is present in the blood and body fluids, its pathogenicity and the potential threat to blood banks. Pending to validate the data published by the WPI in Science with other studies, replicated in independent laboratories, the current estimate of carriers gives a figure of 3.7% of the population, which is currently asymptomatic.
Another study just published in Germany, shows a similar percentage XMRV prevalence in the study population: 3.2%. although this percentage rises close to 10% in patients that have suffered transplants and are taking heavy medications. Given that XMRV shows a very little number in titer, this 10% seems more plausible as a population prevalence. In the same direction points an unpublished study by the FDA and NIH that shows up to 7% prevalence of the retrovirus in the general population.
HISTORY OF A MEDICAL SCANDAL:
The association of XMRV with SFC, is a major milestone in the research of the past 20 years in relation to this disease. The SFC was released in 1984, in Incline Village near Lake Tahoe in Nevada in the U.S. Several hundred people developed some kind of flu that ended in neurological and immunological problems, and suffering several viral infections (CMV, EBV, HHV-6) at a time.
Doctors Paul Cheney and Daniel Peterson asked for help from Centers for Disease Control and Prevention (CDC) in Atlanta, which concluded that these patients were not "ordinary Americans." Thus, the entire responsibility of caring and research, these two young men fell to rural doctors. In the early 90s, everyone was talking about the origin of CFS should be a retrovirus and AIDS specialist, Dr. Nancy Klimas, stated that CFS was a form of acquired immunodeficiency.
In early 1990, a virologist from the Wistar Institute, Dr. Elaine DeFreitas, reported that he had found the DNA of a retrovirus in CFS patients. The CDC is not validated their discovery and publicly criticized claims that their blood samples were contaminated by a "rat virus itself, and thus ending the career of this promising young researcher
Now, 20 years later, when scientific studies linking the SFC again with a retrovirus associated with prostate cancer earlier, both the psychiatric lobby and governments, driven by budgetary interests, strive to return to play down the discovery.
There have been three studies in Europe who took to replicate the study of WPI without following his own mythology, claiming not to have detected the XMRV in European patients. The first negative study is published by the team psychiatrist Simon Wessely - head of the SFC in the UK in January 2010 in a magazine on-line payment.
The second study, also in the UK and with the same result, was followed by a third in Holland last February, with the help of researchers from the UMC St. Radboud, who announced the retrovirus had not found XMRV in Dutchmen patients' blood. However, U.S. investigators said they found it XMRV virus in blood samples from the same patients in 3 of the 7 samples exchanged ( 3 - 9 ). This was a scandal in the press in Holland.
Dr. Suzanne Vernon, virologist with extensive experience, has stated that it can be considered the work published by the British as a valid attempt to replicate the discovery of XMRV since has not followed the methodology that led to the three laboratories Americans to discover the relationship between XMRV and the SFC, and denounced the irregular procedures followed in the British case.
Anticipating what was to happen, the associations of British CFS patients (approximately 250,000 cases diagnosed, and as many undiagnosed according to their estimates), with funds raised by donations from the patients themselves, had already commissioned a laboratory in Sweden retrovirology replication of the discovery, because "they had no assurance that the study be done in Britain came to light a single positive result." Individuals and families are counting on going studies will not show a single positive case of infection in Europe, which would serve their governments as justification for cost-cutting research on these diseases.
In Spain, we have better luck. Retrovirology Laboratory of the Hospital de Badalona Germans Trias has been put to work, and has invited itself Mikovits Judy, who published in Science last October XMRV association with CFS, so that they trained in the difficult and laborious technique has been developed. Unfortunately, this laboratory has not received any subsidy, and are themselves sick, and the United Kingdom, who are paying for the research. SFC also Unit of Hospital del Valle d'Hebron in Barcelona is yet to be approved to start a test study.
In this sense, last May in Madrid held a seminar organized by Red Labs laboratories that are working to develop a diagnostic test XMRV will be ready for the summer of 2010. In the U.S. test is now available.
The controversy over negative studies published flared even more when just days ago was published a fourth study in Europe ( 10 ), where CFS patients are not involved and where it is found in the respiratory tract XMRV of samples asymptomatic people with a prevalence of 3.2% (similar to 3.7% detected in the American study published in Science), and increasing that percentage nearly 10% in immunocompromised patients who had undergone some type of transplant.
These results give reason to believe that the detection rate increased by two possible reasons: The XMRV could be reactivated if there is an immunodeficiency and / or transplant patients may have contracted the XMRV for a transplant or transfusion. In any case not yet confirmed if the retrovirus is the cause or effect of a weak immune system, and therefore remains a suspect trigger diseases like prostate cancer, and SFC among others.
THE XMRV COULD BE A THREAT TO THE HEALTH OF THE RECIPIENTS OF BLOOD TO A TRANSPLANT CANDIDATES. (HHS Blood Safety Committee USA)
The XMRV transmitted through body fluids and various are the countries that have banned blood donations from patients with Chronic Fatigue Syndrome, regardless of health status of patients, in order to prevent infections in donated blood and transplantation. First it was Canada ( 11 ) and has been followed by Australia ( 12 ) and New Zealand ( 13 ), in the U.S. have banned the carrying XMRV donation and is being studied to generalize to patients diagnosed with CFS, but in Europe there has not risen any prohibition or follow any protocol to protect the blood banks.
Any person regardless of sex, age or sexual orientation can get this debilitating disease, which already affects 17 million people worldwide, and while it is confirmed whether the XMRV is cause or effect of CFS, which is known as XMRV is that poses a risk of infection through transfusion or organ transplant ( 14 - 15 ).
The FDA and NIH have confirmed and are about to publish it independently validated study published last October by the group on the XMRV Lombardi. They confirm that the transmission of blood-XMRV is more than probable, and the clear association with CFS. They also confirm that the XMRV and other leukemia-related virus in rodents are present in blood banks with a prevalence between 3% and 7% ( 16 ).
Unfortunately this information was made public by a leak of a journalist Dutchman will not see the light in the short term. The reason that these results of the FDA and NIH are in conflict with a third independent study by a state agency of the U.S. government, the CDC.
Both studies were approved and ready for publication, but the government has decided to push back the publication of positive study of the FDA and the NIH, saying they needed to do more research in the coming weeks to verify "the accuracy" of these results, and yet without changing the study published negative CDC.
It seems that history repeats what has already happened with De Freitas 20 years ago, where he wanted to bury the relationship of a retrovirus with CFS, and now again the government is withdrawing its own study which confirms this relation discovered last Lombardi by the group in October.
The XMRV also be involved in prostate cancer and will hardly be able to bury the truth comes to light, despite wishing to study implicitly censuring the FDA and the NIH as is happening now. But I would welcome the media to take up this history to put pressure on governments and that this study will see the light as soon as possible in their original form as it was when it won approval for publication.
In thesevideos retrieved from the past thanks to the web www.rescindinc.org, we can observe everything that is happening now, rains, it pours, it's the same story of the past.
Now, many years later, a documentary for release in 2011 is telling exactly the same story, and explaining how this whole story has been covered up for all this years, and seems to be covered again after the positive study from FDA and NIH has also been pulled out from release.
The group of patients required written last year by the Ministry of Health in Spain a blood test XMRV within Social Security, to support the clinical diagnosis of Chronic Fatigue Syndrome. However, the Ministry of Health responded that it considered it necessary, and still does not take any measures to protect our blood banks, arguing that only accept samples from people who are in good health.
The problem is that nearly 4% of the asymptomatic population would carry the point XMRV as both the American and German study, published recently. Moreover, some CFS patients have periods of remission can be apparently healthy with the authorities and give blood. In conclusion, not only are not taking any preventive measures in our country to what is a serious potential threat to public health and also to pronounce officially no respect ( 17 ).
This issue is not only exceptionally important for all patients with Chronic Fatigue Syndrome Spanish, who spend years journeying through different doctors until a diagnosis, a test XMRV could become a biomarker and save patients and their families suffering as endless as unnecessary. It is society as a whole that should react by the negligence of the Ministry of Health, which is not taking preventive measures - as it did in the 80s with HIV and hepatitis C - the threat of infection by retroviruses transfusion or transplantation
WHY NOT INVEST IN RESEARCH OF CFS?
In view of Professor Kenny Meirlaen, in a recent television interview of the Netherlands, the reason is obvious, the costs would be enormous for governments to bear when the disease and is more economical relegated to prescribe antidepressants and psychiatric field. It happened with other diseases in the past such as HIV or leprosy, and now hides head in the sand by the side of governments, because they fear what may be discovered ( 18 ).
Chronic Fatigue Syndrome affects 17 million people worldwide, and 240,000 people in Spain, being able to double that figure with the undiagnosed patients. Research spending in the U.S. CDC for CFS is a thousand times lower than the $ 3,000 million per year for HIV research, but paradoxically the prevalence of CFS is twice that of HIV or Multiple Sclerosis. CFS is incurable and any of us can get this disease, and you should care because tomorrow could be you.
Signed. Carlos Gonzalez
The Chronic Fatigue Syndrome (CFS), a disease classified by WHO with the number G 93.3.en ICD-10 is an organic disease, and multisystem disease. You can progressively affect the immune system, neurological, cardiovascular and endocrine systems and cause characterized by severe fatigue, substantial loss of concentration and memory, spatial disorientation, restless sleep, intolerance to light, sound and temperature changes, intolerance to emotional stress and physical activity, muscle aches and joint pain, multiple chemical sensitivities and a permanent flu-like feeling, among other events.
We have also observed severe alterations in the function of NK cells in blood pressure and orthostatic balance, a significant reduction of blood flow to the brain and a reduced ability of oxygen consumption of cells. At the same time, the external appearance of the patient does not reflect the disease: it looks normal.
Reference: VC Lombardi, Ruscetti FW, Gupta JD, MA Pfost, KS Hagen, Peterson DL, SK Ruscetti, Bagni RK, Petrow-Sadowski C, Gold B, Dean M, Silverman RH, and Mikovits JA. Detection of Infectious Retrovirus, XMRV, in Blood Cells of Patients with Chronic Fatigue Syndrome. Online October 8, 2009. Science.
About the oncogenic retrovirus XMRV Whittemore Peterson Institutehttp://www.wpinstitute.org/xmrv/xmrv_qa.html (Official Page WPI)
About the oncogenic retrovirus XMRV National Cancer Institute of the USAhttp://www.cancer.gov/newscenter/pressreleases/XMRV_QandA
Original study published Science magazinehttp://www.sciencemag.org/cgi/data/1179052/DC1/1
Echo of the press in Spain on the news La Vanguardia http://www.lavanguardia.es/participacion/noticias/20091015/53804083772/hallado-un-vinculo-entre-el-retrovirus-xmrv-y-el-sfc-estados-unidos-cancer-salud.html
El Pais http://www.elpais.com/articulo/salud/Eternamente/cansados/elpepusocsal/20100511elpepisal_1/Tes
The World http://www.elmundo.es/elmundosalud/2010/06/28/dolor/1277724239.html http://www.elmundo.es/elmundosalud/2009/09/07/oncologia/1252348915.html
Request of the EMEA (European Alliance ME) to all European countries to ban blood donations from CFS patients proactively to prevent the spread of the retrovirus XMRV in transplantation and transfusion. These measures would follow those taken in Canada, Australia, New Zealand, England, where already banned blood donations from these patients. In the U.S. also has prohibited the donation of the patients who already have confirmed XMRV infection. It only remains to follow Europe http://www.mefmaction.net/MECFSFM/MedicalAuthorities/BloodSupply/BloodDonorsESME/tabid/1207/Default.aspx
http://www.euro-me.org/news-Q22010-005.htm
Scandal in the publication of negative studies XMRV in Europe. It seeks to reach a journalist for news: This article, originally in the Netherlands and translated into English and Spanish, is mentioned all the controversy over the 3 negative studies of XMRV made in England and Holland, where information was withheld, despite knowing before publication. Apparently it was detected the presence of XMRV in the patients studied in the samples that were sent to the U.S., but the study authors silenced these data, which planted a lot of controversy and makes clear that to date there has been a study REPLICA American in Science, where XMRV was detected in the vast majority of patients studied and 4% of healthy controls.
The retrovirus Xenotropic Murine Leukemia Virus Related (XMRV) is a new human pathogen, and possibly the most important scientific discovery since HIV. Has been linked to prostate cancer and Chronic Fatigue Syndrome (CFS).
If confirmed by independent laboratories and the prevalence XMRV association with prostate cancer and CFS according to studies published in the prestigious journal Science, would reach 4% of world population infected, but asymptomatic at this time.
This Retroviruses, in the same family as HIV (AIDS) and HTLV (leukemia), is the third pathogenic retrovirus discovered in humans. Is known to exist for years in mice, but only recently has been discovered in humans, in tissues of patients with prostate cancer. The prostate cancer patients share with Chronic Fatigue Syndrome have altered the antiviral enzyme called RNase-L.
This is the clue that led to Whittermore Peterson Institute (WPI) to connect the two conditions, culminating his studies last October with the publication in Science of a surprising finding, was achieved by isolating the retrovirus XMRV in the nucleus of blood cells 67% of CFS patients and 3.7% of the healthy population. ( 1 - 2 ) After the publication, were improved detection methods and antibodies were found in plasma of 99% of CFS patients, while maintaining the same percentage in the healthy population.
These results have moved scientists around the world to run additional studies that answer the important questions that arise now: modes of transmission of the retrovirus that is present in the blood and body fluids, its pathogenicity and the potential threat to blood banks. Pending to validate the data published by the WPI in Science with other studies, replicated in independent laboratories, the current estimate of carriers gives a figure of 3.7% of the population, which is currently asymptomatic.
Another study just published in Germany, shows a similar percentage XMRV prevalence in the study population: 3.2%. although this percentage rises close to 10% in patients that have suffered transplants and are taking heavy medications. Given that XMRV shows a very little number in titer, this 10% seems more plausible as a population prevalence. In the same direction points an unpublished study by the FDA and NIH that shows up to 7% prevalence of the retrovirus in the general population.
HISTORY OF A MEDICAL SCANDAL:
The association of XMRV with SFC, is a major milestone in the research of the past 20 years in relation to this disease. The SFC was released in 1984, in Incline Village near Lake Tahoe in Nevada in the U.S. Several hundred people developed some kind of flu that ended in neurological and immunological problems, and suffering several viral infections (CMV, EBV, HHV-6) at a time.
Doctors Paul Cheney and Daniel Peterson asked for help from Centers for Disease Control and Prevention (CDC) in Atlanta, which concluded that these patients were not "ordinary Americans." Thus, the entire responsibility of caring and research, these two young men fell to rural doctors. In the early 90s, everyone was talking about the origin of CFS should be a retrovirus and AIDS specialist, Dr. Nancy Klimas, stated that CFS was a form of acquired immunodeficiency.
In early 1990, a virologist from the Wistar Institute, Dr. Elaine DeFreitas, reported that he had found the DNA of a retrovirus in CFS patients. The CDC is not validated their discovery and publicly criticized claims that their blood samples were contaminated by a "rat virus itself, and thus ending the career of this promising young researcher
Now, 20 years later, when scientific studies linking the SFC again with a retrovirus associated with prostate cancer earlier, both the psychiatric lobby and governments, driven by budgetary interests, strive to return to play down the discovery.
There have been three studies in Europe who took to replicate the study of WPI without following his own mythology, claiming not to have detected the XMRV in European patients. The first negative study is published by the team psychiatrist Simon Wessely - head of the SFC in the UK in January 2010 in a magazine on-line payment.
The second study, also in the UK and with the same result, was followed by a third in Holland last February, with the help of researchers from the UMC St. Radboud, who announced the retrovirus had not found XMRV in Dutchmen patients' blood. However, U.S. investigators said they found it XMRV virus in blood samples from the same patients in 3 of the 7 samples exchanged ( 3 - 9 ). This was a scandal in the press in Holland.
Dr. Suzanne Vernon, virologist with extensive experience, has stated that it can be considered the work published by the British as a valid attempt to replicate the discovery of XMRV since has not followed the methodology that led to the three laboratories Americans to discover the relationship between XMRV and the SFC, and denounced the irregular procedures followed in the British case.
Anticipating what was to happen, the associations of British CFS patients (approximately 250,000 cases diagnosed, and as many undiagnosed according to their estimates), with funds raised by donations from the patients themselves, had already commissioned a laboratory in Sweden retrovirology replication of the discovery, because "they had no assurance that the study be done in Britain came to light a single positive result." Individuals and families are counting on going studies will not show a single positive case of infection in Europe, which would serve their governments as justification for cost-cutting research on these diseases.
In Spain, we have better luck. Retrovirology Laboratory of the Hospital de Badalona Germans Trias has been put to work, and has invited itself Mikovits Judy, who published in Science last October XMRV association with CFS, so that they trained in the difficult and laborious technique has been developed. Unfortunately, this laboratory has not received any subsidy, and are themselves sick, and the United Kingdom, who are paying for the research. SFC also Unit of Hospital del Valle d'Hebron in Barcelona is yet to be approved to start a test study.
In this sense, last May in Madrid held a seminar organized by Red Labs laboratories that are working to develop a diagnostic test XMRV will be ready for the summer of 2010. In the U.S. test is now available.
The controversy over negative studies published flared even more when just days ago was published a fourth study in Europe ( 10 ), where CFS patients are not involved and where it is found in the respiratory tract XMRV of samples asymptomatic people with a prevalence of 3.2% (similar to 3.7% detected in the American study published in Science), and increasing that percentage nearly 10% in immunocompromised patients who had undergone some type of transplant.
These results give reason to believe that the detection rate increased by two possible reasons: The XMRV could be reactivated if there is an immunodeficiency and / or transplant patients may have contracted the XMRV for a transplant or transfusion. In any case not yet confirmed if the retrovirus is the cause or effect of a weak immune system, and therefore remains a suspect trigger diseases like prostate cancer, and SFC among others.
THE XMRV COULD BE A THREAT TO THE HEALTH OF THE RECIPIENTS OF BLOOD TO A TRANSPLANT CANDIDATES. (HHS Blood Safety Committee USA)
The XMRV transmitted through body fluids and various are the countries that have banned blood donations from patients with Chronic Fatigue Syndrome, regardless of health status of patients, in order to prevent infections in donated blood and transplantation. First it was Canada ( 11 ) and has been followed by Australia ( 12 ) and New Zealand ( 13 ), in the U.S. have banned the carrying XMRV donation and is being studied to generalize to patients diagnosed with CFS, but in Europe there has not risen any prohibition or follow any protocol to protect the blood banks.
Any person regardless of sex, age or sexual orientation can get this debilitating disease, which already affects 17 million people worldwide, and while it is confirmed whether the XMRV is cause or effect of CFS, which is known as XMRV is that poses a risk of infection through transfusion or organ transplant ( 14 - 15 ).
The FDA and NIH have confirmed and are about to publish it independently validated study published last October by the group on the XMRV Lombardi. They confirm that the transmission of blood-XMRV is more than probable, and the clear association with CFS. They also confirm that the XMRV and other leukemia-related virus in rodents are present in blood banks with a prevalence between 3% and 7% ( 16 ).
Unfortunately this information was made public by a leak of a journalist Dutchman will not see the light in the short term. The reason that these results of the FDA and NIH are in conflict with a third independent study by a state agency of the U.S. government, the CDC.
Both studies were approved and ready for publication, but the government has decided to push back the publication of positive study of the FDA and the NIH, saying they needed to do more research in the coming weeks to verify "the accuracy" of these results, and yet without changing the study published negative CDC.
It seems that history repeats what has already happened with De Freitas 20 years ago, where he wanted to bury the relationship of a retrovirus with CFS, and now again the government is withdrawing its own study which confirms this relation discovered last Lombardi by the group in October.
The XMRV also be involved in prostate cancer and will hardly be able to bury the truth comes to light, despite wishing to study implicitly censuring the FDA and the NIH as is happening now. But I would welcome the media to take up this history to put pressure on governments and that this study will see the light as soon as possible in their original form as it was when it won approval for publication.
In these videos retrieved from the past thanks to the web www.rescindinc.org, we can observe everything that is happening now, rains, it pours, it's the same story of the past.
Click on Video1:
Primetime from Barborka on Vimeo .
Click on Video2:
DVD Video Recording from Barborka on Vimeo .
Now, many years later, a documentary for release in 2011 is telling exactly the same story, and explaining how this whole story has been covered up for all this years, and seems to be covered again after the positive study from FDA and NIH has also been pulled out from release.
Click on Video 3:
What About Me? US Promo (Spanish Subtitles) from Double D Productions on Vimeo .
The group of patients required written last year by the Ministry of Health in Spain a blood test XMRV within Social Security, to support the clinical diagnosis of Chronic Fatigue Syndrome. However, the Ministry of Health responded that it considered it necessary, and still does not take any measures to protect our blood banks, arguing that only accept samples from people who are in good health.
The problem is that nearly 4% of the asymptomatic population would carry the point XMRV as both the American and German study, published recently. Moreover, some CFS patients have periods of remission can be apparently healthy with the authorities and give blood. In conclusion, not only are not taking any preventive measures in our country to what is a serious potential threat to public health and also to pronounce officially no respect ( 17 ).
This issue is not only exceptionally important for all patients with Chronic Fatigue Syndrome Spanish, who spend years journeying through different doctors until a diagnosis, a test XMRV could become a biomarker and save patients and their families suffering as endless as unnecessary. It is society as a whole that should react by the negligence of the Ministry of Health, which is not taking preventive measures - as it did in the 80s with HIV and hepatitis C - the threat of infection by retroviruses transfusion or transplantation
WHY NOT INVEST IN RESEARCH OF CFS?
In view of Professor Kenny Meirlaen, in a recent television interview of the Netherlands, the reason is obvious, the costs would be enormous for governments to bear when the disease and is more economical relegated to prescribe antidepressants and psychiatric field. It happened with other diseases in the past such as HIV or leprosy, and now hides head in the sand by the side of governments, because they fear what may be discovered ( 18 ).
Chronic Fatigue Syndrome affects 17 million people worldwide, and 240,000 people in Spain, being able to double that figure with the undiagnosed patients.
Research spending in the U.S. CDC for CFS is a thousand times lower than the $ 3,000 million per year for HIV research, but paradoxically the prevalence of CFS is twice that of HIV or Multiple Sclerosis. CFS is incurable and any of us can get this disease, and you should care because tomorrow could be you.
Signed. Carlos Gonzalez
The Chronic Fatigue Syndrome (CFS), a disease classified by WHO with the number G 93.3.en ICD-10 is an organic disease, and multisystem disease. You can progressively affect the immune system, neurological, cardiovascular and endocrine systems and cause characterized by severe fatigue, substantial loss of concentration and memory, spatial disorientation, restless sleep, intolerance to light, sound and temperature changes, intolerance to emotional stress and physical activity, muscle aches and joint pain, multiple chemical sensitivities and a permanent flu-like feeling, among other events.
We have also observed severe alterations in the function of NK cells in blood pressure and orthostatic balance, a significant reduction of blood flow to the brain and a reduced ability of oxygen consumption of cells. At the same time, the external appearance of the patient does not reflect the disease: it looks normal.
Reference: VC Lombardi, Ruscetti FW, Gupta JD, MA Pfost, KS Hagen, Peterson DL, SK Ruscetti, Bagni RK, Petrow-Sadowski C, Gold B, Dean M, Silverman RH, and Mikovits JA. Detection of Infectious Retrovirus, XMRV, in Blood Cells of Patients with Chronic Fatigue Syndrome. Online October 8, 2009. Science.
Sources1) http://www.sciencemag.org/cgi/content/abstract/1179052
2) http://www.youtube.com/watch?v=RWOWvdiXiSE
3) http://esme-eu.com/news/dutch-press-release-positive-xmrv-study-a-matter-of-time-article340-7.html
4) http://www.euro-me.org/news-Q22010-004.htm
5) http://www.fibromialgia.nom.es/fibromialgia-Síndrome-de-fatiga-Crónica-Síndrome-quimico-mulltiple-Noticias-2010/Síndrome-de-fatiga-Crónica-positivos-en-estudios-XMRV- single-en-question-de-tiempo.html
6) http://www.wpinstitute.org/news/docs/DearDrMcClureaw4.pdf
7) http://www.wpinstitute.org/news/docs/mclure-wpi_ltr_apr10.pdf
8) http://www.wpinstitute.org/news/docs/wpi-mclure_ltr_apr10.pdf
9) http://www.facebook.com/note.php?note_id=424864330914&id=100000436316743&ref=share
10) http://www.cdc.gov/eid/content/16/6/1000.htm # 1
11) http://www.montrealgazette.com/mobile/iphone/story.html?id=2775203
12) http://news.smh.com.au/breaking-news-national/chronic-fatigue-link-prompts-blood-ban-20100428-trsn.html
13) http://www.stuff.co.nz/nelson-mail/news/national-news/3607226/Chronic-fatigue-donors-face-rejection
14) http://online.wsj.com/article/SB10001424052702303450704575160081295988608.html
15) http://ca.news.finance.yahoo.com/s/18052010/34/biz-f-business-wire-whittemore-peterson-institute-cerus-confirm-inactivation-xmrv-intercept.html
16) http://www.mmdnewswire.com/xmrv-9040.html
http://www.facebook.com/ #! / photo.php? pid = 248 617 & id = 100,000,436,316,743
17) http://xmrv.blogspot.com/2009/12/contestacion-al-ministerio-de-sanidad.html
18) http://www.plataformafibromialgia.org/index.php/prensa/409-entrevista-tv-holandesa-prof-de-meirleir-y-sfc.html
Annexes (Links)
Trailer of the British documentary film about to emerge on the scandal surrounding the XMRV and the SFChttp://www.whataboutme.biz/
In Spanish
http://www.youtube.com/watch?v=tAzpu6qSKCY
http://www.youtube.com/watch?v=xCT1n_y5kos
Petition to ban U.S. official donation of blood from patients with CFS
http://www.aabb.org/pressroom/Pages/cfsrecommendation.aspx
Introducing Erik A. Klein over the possibility of prostate cancer (and CFS) can be infectious diseases XMRV
http://webcasts.prous.com/netadmin/webcast_viewer/Preview.aspx?type=0&lid=11920&eid=574&pv=2&preview=False&idcl=1
About the oncogenic retrovirus XMRV Whittemore Peterson Institutehttp://www.wpinstitute.org/xmrv/xmrv_qa.html (Official Page WPI)
About the oncogenic retrovirus XMRV National Cancer Institute of the USAhttp://www.cancer.gov/newscenter/pressreleases/XMRV_QandA
Original study published Science magazinehttp://www.sciencemag.org/cgi/data/1179052/DC1/1
Echo of the press in Spain on the news
La Vanguardia
http://www.lavanguardia.es/participacion/noticias/20091015/53804083772/hallado-un-vinculo-entre-el-retrovirus-xmrv-y-el-sfc-estados-unidos-cancer-salud.html
El Pais
http://www.elpais.com/articulo/salud/Eternamente/cansados/elpepusocsal/20100511elpepisal_1/Tes
http://lacomunidad.elpais.com/Síndrome-de-fatiga-Crónica-y/2009/10/15/retrovirus-xmrv-mucho-peor-el-virus-la-gripe-a
http://www.elpais.com/articulo/sociedad/Identificado/virus/relacionado/Síndrome/fatiga/Crónica/elpepusoc/20091009elpepusoc_7/Tes
The World
http://www.elmundo.es/elmundosalud/2010/06/28/dolor/1277724239.html
http://www.elmundo.es/elmundosalud/2009/09/07/oncologia/1252348915.html
Request of the EMEA (European Alliance ME) to all European countries to ban blood donations from CFS patients proactively to prevent the spread of the retrovirus XMRV in transplantation and transfusion. These measures would follow those taken in Canada, Australia, New Zealand, England, where already banned blood donations from these patients. In the U.S. also has prohibited the donation of the patients who already have confirmed XMRV infection. It only remains to follow Europe
http://www.mefmaction.net/MECFSFM/MedicalAuthorities/BloodSupply/BloodDonorsESME/tabid/1207/Default.aspx
http://www.euro-me.org/news-Q22010-005.htm
Scandal in the publication of negative studies XMRV in Europe. It seeks to reach a journalist for news: This article, originally in the Netherlands and translated into English and Spanish, is mentioned all the controversy over the 3 negative studies of XMRV made in England and Holland, where information was withheld, despite knowing before publication. Apparently it was detected the presence of XMRV in the patients studied in the samples that were sent to the U.S., but the study authors silenced these data, which planted a lot of controversy and makes clear that to date there has been a study REPLICA American in Science, where XMRV was detected in the vast majority of patients studied and 4% of healthy controls.
http://www.facebook.com/notes/xand-xmrv/se-busca-periodista-noticia-de-alcance/424864330914
Videos explaining the discovery of XMRV and its association with the SFC and prostate cancer.
In Englishhttp://www.youtube.com/watch?v=RWOWvdiXiSE
In Spanishhttp://www.youtube.com/watch?v=bIE97TwawjA
Whittemore Peterson Institute links with all the news so far on the XMRV and its association with Chronic Fatigue Syndrome
http://www.wpinstitute.org/news/news_current.html
http://www.wpinstitute.org/xmrv/xmrv_qa.html
http://www.wpinstitute.org/