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New Research of Interest in Multiple Sclerosis and Chronic Fatigue Syndrome (ME?) - April 2009

Posted Apr 26 2009 10:11pm
Phys Med Rehabil Clin N Am. 2009
May;20(2):325- 337

Functional Neuroimaging of Fatigue

Deluca J, Genova HM, Capili EJ, Wylie GR.

Kessler Foundation Research Center, 1199 Pleasant
Valley Way, West Orange, NJ 07052, USA;
Department of Physical Medicine and Rehabilitation,
University of Medicine and Dentistry of New
Jersey-New Jersey Medical School, Newark, NJ, USA;
Department of Neurology and Neuroscience,
University of Medicine and Dentistry of New
Jersey-New Jersey Medical School, Newark, NJ, USA.

Recent studies employing functional neuroimaging
provide new insights into the elusive construct of
fatigue. Studies have been conducted primarily in
persons with multiple sclerosis (MS) and chronic
fatigue syndrome (CFS).

These studies outline the key role of the basal
ganglia and frontal lobes in understanding the neural
mechanisms associated with fatigue.

The lack of a relationship between self-reported
fatigue and objectively measured fatigue is outlined,
and new functional imaging paradigms may lead to
significant advances in relating cognitive fatigue to
functional cerebral activity.

PMID: 19389614 [PubMed - as supplied by publisher]
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