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Mutant Chronic Hepatitis-B or Hidden Hepatitis-C

Posted Nov 28 2011 7:07pm
Today I am going to talk about something I think is very important for all that you have a diagnosis of CFS.

As you know I have CFS diagnosed for 6 years now, and despite the fact that my serologies for hepatitis A, B and C were negative during these years, this year Gregorio Marañón Hospital and last year Carlos III detected B viruses in my blood test. This came as a surprise because I was vaccinated against Hepatitis B and I already passed Hepatitis A.



As you can see the evolution of these blood tests, surface antigen HBs came out negative ALWAYS, however HBc core antibody was positive on 2 occasions since 2009. Moreover HBe antigen was detected in blood also on two occasions, and there is as well signs of an infectious component when we observe 2 (IL-2R) in December 2010.

The interpretation of this evolution is NOT easy. Firstly because normally is not standardized to test for HBc nor HBe, and secondly because these results may be interpreted in isolation as a "false positive" because they do not fit together well with a negative HBs Ag.

However Gregorio Marañón Hospital advised me to go for a good Liver specialist to undertake a thorough study, because the B virus that they saw was not from the vaccine. For this reason I went to Vicente Carreño, which is the number 1 in Spain.

Dr. Carreño checked my liver with his hands and it was 2 cm rhomboid (sorry for this translation), which signals inflammation, and because of the abnormalities observed in the blood work, He stated that I could be infected with the Hepatitis B virus, despite of the vaccine. Apparently this is a possibility, although not everybody is aware of it.

There are several types of the B virus, and to some of them the vaccine is not effective. Also it can go unnoticed in a normal hepatitis blood work. So He prescribed some special molecular blood work at NUCLEOTEX laboratory in Spain that performs molecular tests to detect two possible cases:

-Hidden Hepatitis C
-Mutant Hepatitis B in Pre-S region

My Results:

Hepatitis B virus:

PCR DNA (ultracentrifugation): 13 copies / ml
HBV-DNA-PCR PBMC NEGATIVE
Proliferation of CD4 + T lymphocytes specific B virus
S (HBs) NEGATIVE
Core (HBc) NEGATIVE
E (HBe) NEGATIVE

Hepatitis C virus:
HCV RNA-(PCR) in PBMC NEGATIVE
PCR-RNA (ultracentrifugation) NEGATIVE
Proliferation of CD4 + T lymphocytes specific to hepatitis C virus
Core NEGATIVE
NS3 (Helicase) NEGATIVE
NS4 NEGATIVE

Although at first glance it seems all negative, it is not. These tests show there is B virus in my blood (13 copies per ml). This is a very low titer, but still shows is positive. At this point is not contagious, but if it peaks, it could be. Another important factor is that the titer might be very low in blood but not necessarily in the liver. It could also be a "false positive" therefore it needs to be confirmed with a biopsy.

For this reason He recommends a biopsy to confirm the infection and liver status, which not only going to look Hepatitis B and C, but also inflammation, tissue conditions, etc. The sample will frozen just in case more things need to be tested at a later stage (i.e. HGRV) .

In view of these results, the observed abnormalities in previous blood test and my clinical history, it is in the opinion of Dr. Carreño a must to perform a biopsy to confirm the findings.

When confirmed, chronic mutant hepatitis B, is treated with retrovirals (Tenofovir), normally for 6 months, given that this kind of hepatitis is more easily cured than regular chronic Hepatitis B.

I've asked him if it is possible that during these 6 years that I have thought to have CFS, perhaps I simply have had chronic mutant Hepatitis B undiagnosed, and his answer was YES.

It is too early to draw conclusions, however I think it's important enough share this writing, when I know the final results of the biopsy I will let you know. If it turns to be the case, I think everyone with a diagnosis of CFS should go through a good hepatologist who can rule out this possibility. Who knows if the people that was XMRV+ and took Tenofovir improved their condition due to an undiagnosed hidden mutant hepatitis B or hidden hepatitis C... that seems to me a plausible chance.

Having normal levels of GPT/GPO, and negative serology for hepatitis is not enough to rule it out as you could see. Not that you can do biopsy directly, first make the liver specialist need to run the molecular blood work, and if the virus is found, it is recommended to run the biopsy to confirm it. To be completely honest, in the opinion of my doctor, even if the blood work came negative He would have recommended a biopsy to make sure, given the many years of symptoms of hepatitis like that I had. Bear in mind that you need a very good specialist that is aware of these advances. They are published by the way.

To be continued ...
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