other (many) sources disagree and can support other evidence of l-glutamine's safety. http://www.longecity.org/forum/topic/43177-glutamine-and-neurotoxicity/
"... the idea that supplemental glutamine is all metabolized to glutamate is simply not the case. Have you ever seen a patient with MSG sensitivity? The symptoms these patients have are the symptoms of excess glutamate: headaches, nausea, dizziness, and this is something I have never seen nor seen reported with high dose glutamine. The body is very good at controlling the Glutamine-Glutamate pathway, which requires B6. I have had many discussions with cell biologist PhDs about this idea that glutamine turns to glutamate at will, and they all say that this is a misstatement, and are particularly critical of Russell Blaylock for making this error in his book.
After all, why doesn't the glutamine all just turn to GABA? Then glutamine would not over excite your neurons, it would put you to sleep. Glutamine clearly does neither".
Glutamine has been known to be extremely safe and beneficial even in huge doses for decades. Some people just try to make a name and career for themselves by issuing panicky warnings about all sorts of things - it's the internet, often used with an ulterior motive for marketing. It's important to study, but I'm not so sure the internet is the best way to do all research, unless you like conflicting opinions and overwhelm. You WILL be able to find info that supports either direction.
another source: http://www.listen2yourgut.com/blog/l-glutamine-usage-with-children/
Here’s the result of my research and my personal opinion on the topic:
Kids with sickle cell anemia need higher amounts of L-glutamine. So this study assessed response/effects with a massive dosage of 600 mg of L-Glutamine per 1 kg of body weight. Which means, for example, that a child weighing 44 pounds would ingest 12,000 mg of L-Glutamine per day. Even at that very high dose, this study (below) on children as young as 5 years old showed no negative effects of supplementation.
also on the same site -
L-Glutamine is only a problem when you ingest MORE than your body needs, or can utilize. For anyone in a disease state, their requirements are going to be much higher since the body is engaged in ongoing repair of damaged tissue.
And just for another counter to the claim that L-Glutamine can cause mental retardation, I found a few studies done using L-Glutamine with Attention Deficit Disorder children, that show that supplementation INCREASES mental ability. Here’s one example:
“Intellectually impaired children and adults often show an increase in IQ after taking glutamine in combination with Ginkgo biloba and B6. Dr. Roger Williams demonstrated that children and adults diagnosed with ADHD showed a marked improvement when taking 250 mg to 1,000 mg of glutamine daily. Dr. C. Fredericks research also demonstrated a definite increase in the IQs of children given glutamine. When glutamine was given daily, children showed impressive improvements in their abilities to learn, to retain, and to recall. Glutamine is a major part of my orthomolecular program for hyperactive and ADHD children. Glutamine is one of the amino acids that create the neurotransmitters in the brain that enhance learning and memory. Hyperactive and ADD children have lowneurotransmitter levels, especially glutamine. Adding glutamine increases the level of neurotransmitters. Start with 500 mg of glutamine and gradually increase until you reach the optimal dose for your child, to a maximum of 3,000 mg per day.“
- ADD & ADHD Natural Control of ADD & ADHD
Billie J. Sahley, Ph.D., CNC
So, the best route, as always, is to “listen to your gut” – and more importantly, listen to your child’s gut. She/he will let you know if it’s good for him/her, or not. And if you want to follow pre-established limits, as evidenced in clinical trials, then these indicate that you can safely give your child anywhere from 3,000 – 10,000 mg per day (depending on the study).
(((WOW up to 10,000??!! - Angelina insertion)
Don’t forget, many health sites are purposely looking for information that they can present in a shocking or “groundbreaking” way – this increases their subscribers and also gets higher readership of their newsletters (thus driving more people to their site). So try to be discriminating and don’t over-react to new findings until you have done your research and put it into context. It may be 100% valid, and it may not.
[I couldn't agree with what she just said more...]
Jini Patel Thompson’s books on natural healing for digestive diseases have sold in over 40 different countries. Her health articles have been published in journals and magazines in the U.S., Australia and U.K.
Now I personally would not and did not give my child that many mg a day!! only 125mg... it was merely a delivery agent for the AMP aloe mucilaginous polysaccharide I was giving her, which did absolute wonders for her bowel problems. She is a super- bright, healthy 5 year old to this day - a bit spirited and dramatic, but smart as a whip with no signs of brain damage. Well... except for those pesky sinus problems we all have here in the southeast...
I could go on with more sources, but it truly is conflicting and overwhelming, and hard to know what sources online to trust, as much as it is hard to find the right healthcare professional at all these days. I hope that what happened to your child was NOT due to a poor unqualified practicioner, but I suppose that's a risk one takes when seeking out a professional to trust. Sometimes I wonder if the internet is a blessing or a curse.