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Do Blood Pressure Drugs Reduce the Risk of Dementia?

Posted Jan 08 2013 9:33am
People taking blood pressure drugs called beta blockers may be less likely to have changes in the brain that can be signs of Alzheimer’s disease and other types of dementia .

Alzheimer's Reading Room

Do Blood Pressure Drugs Reduce the Risk of Dementia?
The research study described below indicates that beta blockers , a class of blood pressure drugs, may help protect the aging brain against changes linked to Alzheimer's disease and other forms of dementia.

Previous studies have shown that high blood pressure in mid life can increase the risk of Alzheimer's and dementia.

In addition, a parallel study showed that an expanded group of men who took beta blockers also experienced less cognitive decline as they aged compared with those in the control groups.

I would suggest you share this information with family, relatives, and friends; and, discuss these findings with your doctor. I would also suggest you share this with persons who are currently in mid life (in their forties).

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Can Blood Pressure Drugs Reduce the Risk of Dementia?

People taking the blood pressure drugs called beta blockers may be less likely to have changes in the brain that can be signs of Alzheimer’s disease and other types of dementia, according to a study released today that will be presented at the American Academy of Neurology’s 65th Annual Meeting in San Diego, March 16 to 23, 2013.

The study involved 774 elderly Japanese-American men who took part in the Honolulu-Asia Aging Study .

Autopsies were performed on the men after their death. Of the 774 men, 610 had high blood pressure or were being treated with medication for high blood pressure. Among those who had been treated (about 350), 15 percent received only a beta blocker medication, 18 percent received a beta blocker plus one or more other medications, and the rest of the participants received other blood pressure drugs.

The study found that all types of blood pressure treatments were clearly better than no treatment. However, men who had received beta blockers as their only blood pressure medication had fewer abnormalities in their brains compared to those who had not been treated for their hypertension, or who had received other blood pressure medications.

The brains of participants who had received beta blockers plus other medications showed an intermediate reduction in numbers of brain abnormalities.

These included two distinct types of brain lesion: those indicating Alzheimer’s disease, and lesions called microinfarcts, usually attributed to tiny, multiple, unrecognized strokes.

Study participants who had taken beta blockers alone or in combination with another blood pressure medication had significantly less shrinkage in their brains.
“With the number of people with Alzheimer’s disease expected to grow significantly as our population ages, it is increasingly important to identify factors that could delay or prevent the disease,” said study author Lon White, MD, of the Pacific Health Research and Education Institute in Honolulu. “These results are exciting, especially since beta blockers are a common treatment for high blood pressure.”
Earlier research has shown that high blood pressure in midlife is a strong risk factor for dementia.

The study was supported by the National Institutes of Health.

The American Academy of Neurology , an association of more than 25,000 neurologists and neuroscience professionals, is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimer’s disease, stroke, migraine, multiple sclerosis, brain injury, Parkinson’s disease and epilepsy.

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Original content Bob DeMarco, the Alzheimer's Reading Room
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