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'Trojan Horse' Therapy Kills Cancer Cells

Posted Jul 21 2009 10:26am

'Trojan Horse' Therapy Kills Cancer Cells

Australian researchers are set to begin human trials of a tiny nano-cell that acts as a "Trojan horse" against cancer cells, a breakthrough they say may curb the need for debilitating chemotherapy.

The technology could eventually allow cancer sufferers to receive treatment as outpatients, rather than being hospitalized for lengthy bouts of chemotherapy, according to the researchers.

The research, outlined in the journal Nature Biotechnology, has the potential to reduce the side effects of cancer treatment and make it cheaper.

The technology allowed medics to target cancer cells without damaging healthy tissue, a major problem with existing chemotherapy treatments and essentially you need to get the drug directly inside the cancer cell and not slug the body.


While researchers have been working on using nano-cells against cancer for at least five years, the Australian researchers said the latest version had proved 100 percent effective in treating cancers in mice which were resistant to conventional chemotherapy.

The cells were loaded with anti-cancer medications and deployed in "waves" to combat cancers. The first wave of Trojan horses goes in there and disables the resistance mechanisms inside the cancer cell.

These cancer cells are totally receptive to repeated waves of these Trojan horses. They can send in these nano-cells again and again and each time they can load them up with different types of armaments against cancer.

The cells will be tested on long-term cancer patients at three Melbourne hospitals this year. The researchers have stated that the nano-cells used less drugs than conventional treatments, making them cheaper to administer, and that the targeted treatment also means they have less side effects than chemotherapy.

Cancer treatment effectively can change to literally an outpatient therapy, where the patient simply comes in once or twice a week.  You can receive the treatment in a very short period of time and you can go about your normal life and not have any of these horrific toxic side effects.

 

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