“When I was told it was cancer, it was a shock at first. They went through the options for treatment and mentioned the trial. You just think about getting well and I gave permission to try it. I was keen to get rid of the tumour. You put your life in their hands and the outcome has been good – it is 13 years next month. I can’t believe it”.
On the trial, she did experience some side-effects. “It is bad going through that, as they are strong treatments. There are times when you cannot see the light at the end of the tunnel, but you get there and you have to see that it is going to make you well.”
Each year over 30,000 people take part in trials funded by Cancer Research UK. And it’s thanks to people like Wendy that we are able to continue this lifesaving work. She added:
“I feel I am lucky that it did all work. I did have side-effects and it has all been a hard journey but it is worth it.
“I have had regular cystoscopies since and am all clear again. I have a cancer clinic appointment once a year.
She’s back to normal now and glad she helped make a difference. “I am all for trials. It is really good they are coming up with new things.
The success of the trial meant that the treatment could progress on to a larger phase III randomised trial – funded by Cancer Research UK – the results of which are published in the New England Journal of Medicine.
Three hundred and sixty patients from around the UK took part, around half of which received chemoradiotherapy and the remainder of which had the standard radiotherapy treatment.
Among those who had chemoradiotherapy, around 33 per cent had a relapse in their bladder or the surrounding tissues within two years, compared to 46 per cent in the group that had radiotherapy alone (a reduction of around a third).
And when the team looked at the risk of potentially lethal invasive cancer returning, the improvement was even more marked. People who were only given radiotherapy were about twice as likely to relapse with invasive disease than those who had chemoradiotherapy.
Early results also showed chemoradiotherapy may improve survival, with 48 per cent of patients still alive after five years, compared to 35 per cent of those who had radiotherapy alone. But larger studies will be needed to confirm this.
“These findings provide a new ‘gold standard’ of treatment that will be particularly important for elderly patients, because surgery to remove the bladder in this age group can have a severe impact on quality of life.
“Survival rates for bladder cancer have been increasing in recent years, with around half of patients now surviving 10 years or more, compared to around a third in the 1970s. But bladder cancer is largely a disease of older people and, with an ever ageing population, it’s essential that there are alternative treatments suitable for this age group,” Kate Law, director of clinical research at Cancer Research UK, told us.
And as well as showing how clinical trials can improve things, this story demonstrates that, alongside the excitement about new, personalised therapies, sometimes new combinations of existing treatments can have just as much of an impact on patients’ lives.
For more information about this trial and others, please visit CancerHelp UK or call the Cancer Research UK cancer information nurses on 0808 800 4040.