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The Role of Inflammation in Cancer

Posted Sep 28 2011 12:49pm

Highlights
Precancerous inflammation can cause increased genetic and epigenetic damage Aberrant oncogenic signaling can induce inflammation The inflammatory response in cancer tissues elicits tumor tissue remodeling and metastases
Brief summary:


Cancer related inflammation can fall into one of two categories: 1. precancerous inflammation lesions and 2. Inflammation that is present in almost all cancer tissues including those that have no precancerous inflammation lesions. The connection between inflammation and cancer can be thought of as consisting of two pathways: an extrinsic mechanism, where a constant inflammatory state contributes to increased cancer risk (such as inflammatory bowel disease); and an intrinsic mechanism, where acquired genetic alterations (such as activation of oncogenes) trigger tumor development (Fig. 1).



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