More than 500,000 women in the U.S. are taking tamoxifen and about 30% of those women are also prescribed antidepressants. A recent study in 2009 ASCO raised the possiblity that tamoxifen interacts negatively with newer anti-depressants. The retrospective study involved about 1,300 women who were taking antidepressants like Paxil, Prozac and Zoloft along with tamoxifen for at least one year had a breast-cancer recurrence rate of 16% -- compared with a recurrence rate of 7.5% for women not taking the drugs. However,women on drugs like Celexa, Lexapro and Luvox didn't have a statistically higher rate of cancer recurrence. However, a similar study, also presented at the meeting, showed no effect of SSRIs on the risk for breast cancer recurrence in women taking tamoxifen. This study was conducted in the Netherlands, and involved 1962 women who were taking tamoxifen after surgery for early-stage breast cancer. About 11% had also taken an SSRI (most commonly fluoxetine and paroxetine) at some point.
The association has been found again in a 2010 study of 2,430 elderly women (66 years or older) with breast cancer who were treated with tamoxifen and a single selective serotonin reuptake inhibitor, most commonly paroxetine, between 1993 and 2005.
After adjusting for several factors, overlapping treatment with tamoxifen and paroxetine was associated with a higher risk of death from breast cancer, and a greater extent of overlap was associated with a greater risk of death. For the median overlap of 41 percent, the authors estimated that there would be one additional breast cancer death for every 19.7 patients within five years of stopping tamoxifen treatment. The editoial that accompanied this article in the British Medical Journal recommended avoidance of strong CYP2D6-inhibiting SSRIs, such as paroxetine and fluoxetine, and consider instead drugs with low potential to inhibit CYP2D6, such as citalopram or venlafaxine, they write.
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