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SiRNAs regulate angiogenesis through endothelial progenitor cells

Posted Aug 01 2012 4:10am

Bone marrow-derived endothelial progenitor cells (EPCs) contribute to the phenomenon of angiogenesis-dependent growth in mice and human tumors. Endothelial progenitor cells through paracrine vascular growth factor and promoting the lumen of new blood vessels directly into the germination state to regulate the angiogenic switch.
Micro RNA (miRNA) is a key regulator involved in a variety of biological processes, including angiogenesis. However, wheter miRNA contributes to the angiogenesis mediated by bone marrow-derived endothelial progenitor cell, remains unknown.

Recently, a new study suggested that after enzyme Dicer was processed by the genetic ablation siRNA, circulating endothelial progenitor cells declined in the number, leading to angiogenesis inhibition and tumor growth being impaired.
In addition, deep sequencing of small RNA genome reveals miR-10b and miR-196b are tumor EPC intrinsic miRNA, which have been previously identified as a key regulator of HOX signals and adult stem cell differentiation.It is worth noting that the researchers found that miR-10b and miR-196b were responded  to the stimulation of vascular endothelial growth factor (VEGF) ,and both elevated expression in human breast tumor vasculature.Strikingly, the role of miR-10Band miR-196b lead to the inhibition of angiogenesis-mediated tumor growth . It may be a new strategy to inhibit tumor angiogenesis by targeting these miRNAs.
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